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- Focuses on the topic of brain metastases
- Provides a comprehensive guide to brain metastasis pathophysiology and management
- Presents new therapeutic strategies, such as surgical techniques, radiation therapy techniques and new systemic treatment approaches, including targeted- and immunotherapy
This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors. Table of Contents- Epidemiology of Central Nervous System Metastases
- Pathology of Brain Metastasis
- Molecular Mechanisms in Brain Metastasis
- Genomic Characterization of Brain Metastases: Implications for Precision Medicine
- Brain Metastases Cell Partners and Tumor Microenvironment
- Liquid Biopsy Diagnosis of CNS Metastases
- Preclinical Models of Brain Metastases
- Clinical Presentation of Brain Metastases
- Epilepsy in CNS Metastases
- Safety, Tolerability, and Use of Steroids
- Anticoagulation in Patients with Brain Metastases
- Imaging of Brain Metastases: Diagnosis and Monitoring
- Metabolic Imaging of Brain Metastasis
- Clinical, Imaging, and CSF Cytological Presentation of Leptomeningeal Metastases from Solid Non-CNS Primary Tumors
- Surgery in Brain Metastasis Management: Therapeutic, Diagnostic, and Strategic Considerations
- Surgical Resection for Brain Metastases
- Stereotactic Radiosurgery for Brain Metastases
- Whole Brain Radiotherapy (WBRT) for Brain Metastases
- Combining Radiosurgery and Systemic Therapies for Treatment of Brain Metastases
- Brain Metastases from Lung Tumors
- Current Treatment Strategies in Breast Cancer Brain Metastases
- Management of Melanoma Brain Metastasis
- Miscellaneous Metastases
- Treatment of Leptomeningeal Metastases
- Neurocognitive Toxicity from Radiation Therapy for Brain Metastases
- Neurological Complications of Chemotherapy
- Neurological Complications of Targeted Therapies
- Neurological Complications of Immune-Based Therapies
- Health-Related Quality of Life Related to Toxicity Treatments in Central Nervous System Metastases
- Prognostic Indices for Patients with Brain Metastases
- Prevention Strategies for Brain Metastasis
- Clinical Trials: Endpoints and Outcome Assessment
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