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Falls, fractures, frailty, osteoporosis and sarcopenia are highly prevalent in older persons. While the concept of osteosarcopenia is new, it is a rapidly evolving and cross-disciplinary problem. Prevention and treatment are challenging and a combined therapeutic approach is needed. Osteosarcopenia provides evidence-based information on how to prevent and treat these conditions at multiple settings, including multiple illustrations, care pathways and tips to easily understand the pathophysiology, diagnostic methods and therapeutic approach to these conditions. This work evaluates the potential for a link between osteoporosis, sarcopenia and obesity. - Presents diagnostic and therapeutic tips that facilitate the design and implementation of new care pathways, impacting the wellbeing of our older population
- Provides cross-disciplinary understanding by experts from the bone/osteoporosis field and the muscle/sarcopenia field
- Covers muscle and bone biology, mesenchymal stem cells, age-related changes and cross-talk between muscle, fat and bone, falls and fracture risk, glucose metabolism, diagnosis, imaging, and genetics of osteosarcopenia
Table of Contents- 1. Muscle and bone biology - Similarities and differences
- 2. Mesenchymal stem cells as regulators of bone, muscle and fat formation
- 3. Age-related changes in muscle, fat and bone: Their impact on metabolism and function.
- 4. Cross-talk between muscle, fat and bone
- 5. Falls and fracture risk assessment - The role of osteoporosis, obesity and sarcopenia.
- 6. Good and bad fat in osteosarcopenia
- 7. Glucose metabolism and osteosarcopenia
- 8. Diagnosis of osteosarcopenia - Clinical
- 9. Diagnosis of osteosarcopenia - Imaging
- 10. Genetics of osteosarcopenia
- 11. Non-pharmacological interventions for osteosarcopenia
- 12. Pharmacological treatments of osteosarcopenia
- 13. Social impact of osteosarcopenia
- 14. Models of care for falls and fracture prevention
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