Posttraumatic Epilepsy: Basic and Clinical Aspects provides a synthesized resource on recent basic and clinical science developments in the field of posttraumatic epilepsy.
The book provides a clear understanding of the history of studies of posttraumatic epilepsy and the military and civilian data regarding risk of epilepsy after head trauma. It also covers the basic science of animal models of head injury and the necessary and sufficient changes that must occur to generate epilepsy after head trauma. The authors also explore novel therapeutic approaches to prevent posttraumatic epilepsy.
It is written for basic and clinical researchers in neuroscience, as well as clinicians treating patients with epilepsy.
Features:- Synthesizes studies that demonstrate risk factors for susceptibility to epilepsy after head trauma
- Reviews animal models of head injury
- Explores novel therapeutic approaches to prevent posttraumatic epilepsy
Table of Contents- 1. History of posttraumatic epilepsy
- 2. Epidemiology of posttraumatic epilepsy (from military and civilian data sources)
- 3. Neuropathology of posttraumatic epilepsy
- 4. Clinical trials of agents to prevent posttraumatic epilepsy
- 5. Surgical treatment of posttraumatic epilepsy
- 6. Animal models of traumatic brain injury
- 7. Incidence of posttraumatic epilepsy in animal models of traumatic brain injury
- 8. Cellular and molecular changes in animal models of posttraumatic epilepsy
- 9. Blood-brain barrier disruption and posttraumatic epilepsy
- 10. Inflammation and posttraumatic epilepsy
- 11. Treatment trials in animal models to prevent posttraumatic epilepsy
- 12. Therapeutic targets and future directions
