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X-Ray Phase-Contrast Tomography

BROMBAL --- Neuerscheinung!!

X-Ray Phase-Contrast Tomography
Underlying Physics and Developments for Breast Imaging

140 Seiten, 1. Auflage, 2021
68 Abbildungen

  • Nominated as an outstanding PhD thesis by the Italian National Institute of Nuclear Physics and the University of Trieste
  • Makes important contribution to the optimization of x-ray tomography using synchrotron radiation
  • Adds to the weight of evidence supporting the transition of phase contrast imaging from synchrotrons to hospitals
X-ray imaging is a corner stone of breast cancer diagnosis. By exploiting the phase shift of X-rays rather than their attenuation, phase-contrast tomography has the potential to dramatically increase the visibility of small and low contrast features, thus leading to better diagnosis.

This thesis presents research on the first synchrotron-based project developing a clinical phase-contrast breast computed tomography (CT) setup at Elettra, the Italian Syncrotron Radiation Facility. This book includes a comprehensive theoretical background on propagation-based phase-contrast imaging, exploring and extending the most recent image formation models. Along with theory, many practical implementation and optimization issues, ranging from detector-specific processing to setup geometry, are tackled on the basis of a large number of experimental evidences.

Most of the modelling results and data analysis have general validity, being a valuable framework for optimization of phase-contrast setups. Results obtained at synchrotron are also compared with "real world" laboratory sources: both a first-of-its-kind comparison with one of the few hospital breast CT systems and a state-of-the-art implementation of monochromatic phase-contrast micro-tomography with a conventional rotating anode source are presented. On a more general level, this work sheds a light on the importance of synchrotron-based clinical programs, which are key to trigger the long-anticipated transition of phase-contrast imaging from synchrotrons to hospitals.

Table of Contents
  • Introduction.-
  • Physics of Propagation-based X-ray Tomography.-
  • Propagation-based Breast CT and SYRMA-3D Project.-
  • Detector and Pre-processing.-
  • Experimental Optimization of Propagation-based BCT.-
  • Three-Dimensional Imaging: A Clinically Oriented Focus.-
  • Do We Need Clinical Applications in Synchrotrons?.-
  • Conclusions.

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