Genetics, Neurology, Behavior, and Diet in Dementia


MARTIN / PREEDY
Genetics, Neurology, Behavior, and Diet in Dementia The Neuroscience of Dementia, Volume 2
952 Seiten, 1. Auflage, 2020

Offers comprehensive coverage of a broad range of topics related to dementia Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about dementia Table of Contents: I. Genetics, Molecular and Cellular Biology 1. The genetics of Alzheimer’s disease: a focus on the neuron navigator 2 gene 2. Interlinking polymorphisms, estrogens and Alzheimer’s disease 3. Linking EEGs, Alzheimer’s disease and the Phosphatidylinositol binding clathrin assembly protein (PICALM) gene 4. CD36 gene polymorphism and Alzheimer’s disease 5. Genetic contributions to sporadic frontotemporal dementia 6. Dementia and CYP2D6 polymorphisms 7. A1 purinergic receptor gene expression in dementia 8. Molecular aspects of metallothionein-1 in dememtias 9. MicroRNAs in Alzheimer's disease 10. Oxidative stress and neurons in dementia 11. Toward an integrative understanding of the neuroinflammatory molecular milieu in Alzheimer's disease neurodegeneration 12. Wnt Signalling and dementia 13. Linking PKC, PKClambda/I and Alzheimer’s disease 14. Linking histone deacetylases, phosphodiesterase 5 and novel treatments Alzheimer’s disease 15. Linking Nrf2 and Alzheimers diseas 16. Role of alpha- and beta-secretase in Alzheimer’s disease 17. Methylation analysis of DNA in Alzheimer’s disease 18. The signalosome malfunctions in age-associated neuropathologies 19. ILEI/FAM3C in Alzheimer’s disease 20. Amylin and Alzheimer’s disease 21. Mammalian target of rapamycin (mTOR) complexes: Regulation and Alzheimer's disease 22. Mammalian target of rapamycin (mTOR) complexes: Protein synthesis and autophagy, Parkinsons Disease, Amyotrophic Lateral Sclerosis and frontotemporal dementia 23. Linking CD200 in brains and dementia: molecular aspects of neuroinflammation II. Neurological, Physiological and Imaging 24. Hippocampal atrophy and dementia 25. Inflammation and insulin resistance in AD: partners in crime 26. Neuronal susceptibility to hypoxia in Alzheimer disease 27. Neuropeptides and Neurolipids: what they are and how they relate to Alzheimers disease 28. Brain receptors in Alzheimer’s disease 29. Abeta42-alpha7-like nicotinic acetylcholine receptors and Alzheimer’s disease 30. Synaptosomal bioenergetics in Alzheimer’s disease 31. Limitations of amyloid-PET imaging 32. Linking Gradient Echo Plural Contrast Imaging (GEPCI) Metrics of Tissue Microstructure with Alzheimer 33. Hypertensive disorders in pregnancy and later dementia 34. Sleep architecture and the development of clinical dementia III. Behaviour and Psychopathology 35. An overview of behavioural and psychiatric symptoms of dementia 36. Delirium superimposed on dementia: from diagnosis to treatment 37. Self-Consciousness Deficits in dementia 38. Attention impairements, novel images and Alzheimer’s disease 39. Frontal Lobe Syndrome and Dementias 40. The stigma of dementia 41. Delusions in dementias 42. Linking motor speech function and dementia 43. Spatial Navigation and Alzheimer’s disease 44. Violence and dementia 45. Caregiver depression in dementia IV. Diet, Nutrition and Environment 46. Nutritional status in dementia 47. Selenium and Alzheimer’s disease 48. Linking adiponectin and obesity in dementia 49. The gut microbiome in Alzheimer's Disease 50. (-)-epigallocatechin-3-gallate (EGCG) and Alzheimer disease 51. Cadmium and Alzheimer’s disease V. Models And Modelling In Dementia 52. Alzheimer's model 5xFAD mice as a model and applications to dementia 53. Use of 192 IgG-saporin as a model of dementia and its application 54. Abeta1-42 oligomer animal model of dementia Resources

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