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The increasing pace of advances in cardiology throughout the last few decades has fundamentally altered the natural course of heart patients. In the last few years, available therapies have been revolutionized completely by new transcatheter therapeutic approaches, novel ventricular assist devices, and new drugs. Also, molecular biology and genetics have a rapidly growing impact on cardiovascular diseases, enabling the field of regenerative medicine to become increasingly closer to routine clinical implementation. Emerging Technologies for Heart Diseases was conceived to cover the recent extensive literature on current and novel therapeutic options for cardiac patients. The first volume is dedicated to heart failure and valvular disorders, and the second covers myocardial ischemia and arrhythmias. The clinical topic is addressed in several chapters divided according to the therapeutic approach (mechanical or electrical device-based, or cell and gene-based). Each of the 46 chapters focuses on clinically available solutions, new therapies currently under evaluation in clinical trials, promising preclinical technologies, and emerging concepts and innovations that have not yet been tested in a preclinical model. Also, the book discusses future challenges and opportunities for clinical implementation. Lessons learned from abandoned experimental practices are also covered, giving the readers the widest possible perspective of current therapeutic dilemmas. Overall, this textbook was designed for physicians who want to stay up-to-date with current therapies and those of the future, for biomedical companies, and for those who wish to broaden their knowledge of new cardiovascular therapeutic options. Features:- Provides a comprehensive review of the latest therapeutic developments for heart failure, valvular disorders, myocardial ischemia and arrhythmias, and their clinical implications
- Written by both specialists in the field and established researchers, it delivers a review of emerging medical technologies and presents insight into their therapeutic promise
- Chapters are arranged according to disease pathogeneses and relevance and include coverage of the mechanical, electrophysiological, and biological approaches for the management of patients with heart failure should be replaced with heart failure and valvular disorders
Table of ContentsSECTION 1: Treatment of heart failure - device-based therapies and monitoring modalities- 1. Keeping a Finger on the Pulse - A brief history of cardiovascular medicine
- 2. Artificial mechanical hearts and ventricular assist devices
- 3. Percutaneous left and right ventricular support devices
- 4. Cardiac resynchronization therapy
- 5. Left atrial decompression devices
- 6. Device-based treatment for diastolic heart failure
- 7. Ultrafiltration and other treatments of volume overload in congestive heart failure
- 8. Cardiac physical remodeling and percutaneous solutions for the treatment of advanced Heart Failure
SECTION 2: Treatment of systolic heart failure - cell and gene-based therapies, tissue engineering and biopolymers- 9. Cardiac xenotransplantation
- 10. Marrow-derived stromal cells for cardiac regeneration
- 11. Heart-derived cells for therapeutic application
- 12. Human Pluripotent Stem Cells for Cardiac Regeneration
- 13. Heart Regeneration Using Somatic Cells
- 14. In-vitro engineered heart tissue grafts
- 15. Decellularization of whole hearts for cardiac regeneration
- 16. Gene and protein-based therapies for improving cardiac performance and regeneration
- 17. Biopolymers in the treatment of heart failure and cardiac remodeling
SECTION 3: Treatment of systolic heart failure - novel pharmacological treatments- 18. Novel pharmacotherapies for the treatment of heart failure
SECTION 4: Treatment of valvular disorders- 19. Heart Valve Tissue Engineering: Current Preclinical and Clinical approaches
- 20. Transcatheter aortic valve replacement
- 21. Transcatheter mitral valve repairs for degenerative and Functional mitral regurgitation
- 22. Transcatheter mitral valve implantation
- 23. Transcatheter treatments for tricuspid valve diseases
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