- Uses multidisciplinary approach to demonstrate dysregulation of cellular redox status in the manifestation of different types of heart diseases
- Describes the second messenger properties of ROS to activate signalling pathways involving different types of kinases, phosphatases, transcription factors and ion channels
- Discusses different targets for drug development in cardiovascular diseases
This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease. Each chapter in the book deals with the role that altered redox homeostasis plays in the pathophysiology of heart disease.
In addition, the book explains how reactive oxidant species interact with their targets and provides novel strategies for attenuating oxidative stress-induced types of heart disease.
The book not only covers ROS-induced response in heart disease at the cellular level, but also demonstrates that an imbalance of redox states has its roots in our genes, and explains the ways gene expression is regulated. In turn, it reviews potential sources of ROS, their pathological effects on the heart, and potential sites for therapeutic interventions.
Table of ContentsA. Regulation of Oxidative Stress- 1. Impact of genetic and epigenetic factors on the oxidative stress in cardiovasculardisease
- 2. Role of aging and metabolic disease in oxidative stress of heart
- 3. Role of monoamine oxidases in heart diseases
- 4. Role of miRNA in oxidative stress induced heart diseases
- 5. Modulation of Oxidative (stressed) Heart Disease by Uncoupling Proteins
- 6. Redox regulation in heart by ion channels
- 7. Molecular regulators in ROS mediated cardiac diseases
- 8. The inflammatory stress that follows preceded oxidative stresses in the pathogenesisof heart diseases
- 9. Metabolic signatures of redox-dependent cardiovascular disease
- 10. Role of heat shock proteins in oxidative stress induced heart diseases
B. Pathophysiology of Oxidative Stress- 11. Oxidative stress in metabolic syndrome : experimental model of biomarkers
- 12. Oxidative stress as a critical determinant of adult cardiac progenitor cell-fatedecisions
- 13. Role of oxidative stress in hyperhomocysteinemia-induced heart disease
- 14. Oxidative Stress and the Aging Heart
- 15. Basic mechanisms of ischemia/reperfusion injury leading to cellular and tissuedamage
- 16. Oxidative stress in congenital heart defects
- 17. Nitrosative stress and cardiogenesis: Cardiac remodeling perturbs embryonicmetabolome
- 18. Oxidative Stress and Mitochondrial Dysfunction in Heart Diseases
- 19. Role of oxidative stress, mitochondrial dysfunction and autophagy in cardiovasculardisease: Its pathogenesis and amelioration by different small natural molecules
- 20. Regulation of cardiac ion channels in stress related heart diseases
- 21.In silico perspectives of the mechanism of oxidative stress during the onset of heartdisease
- 22.Biomarkers of oxidative stress and endothelial dysfunction in the elderly: oxidizedLDL versus LDL oxidizability
C. Prevention & therapeutics- 23. Restoring nitroso-redox balance as a therapeutic for heart disease
- 24. Oxidative stress role in cardiovascular prevention and disease
- 25. Mitochondrial dynamics and mitophagy in heart: role in disease and interventionalopportunities
- 26. Role of exercise in prevention and treatment of heart diseases: focus on redox balance
- 27. Mitochondrial biology and its therapeutic use in cardiovascular disease
- 28. Oxidative stress-driven cardiotoxicity of cancer drugs
- 29. Modifying redox signaling to enhance success of regenerative therapy in the heart
