Features:- Provides comprehensive and cutting-edge knowledge of whole pancreas and islet transplantation
- Addresses imaging, treatment, scaffold technology, the use of stem cells to generate insulin, 3D printing, and more
- Offers an update on the progress of regenerative medicine research aimed at beta cell replacement for the treatment of diabetes
Table Of Contents:PART A. ISLET ALLO-TRANSPLANTATION
Section I. Chronic Pancreatitis
- 1. Etiopathogenesis and Pathophysiology of Chronic Pancreatitis
- 2. Non-Replacement Treatment of Chronic Pancreatitis: Conservative, Endoscopic and Surgical (Resection and Drainage Procedures)
Section II. Islet Auto-Transplantation for Chronic Pancreatitis
- 3. Requirements for clinical islet laboratories
- 4. Islet Isolation for Autotransplantation, following Total or Near Total Pancreatectomy
- 5. Strategies to improve islet yield from chronic pancreatitis pancreases intended for islet auto-transplantation
- 6. Surgical Techniques for Total Pancreatectomy and Islet Autotransplantation
- 7. Total Pancreatectomy with Islet Autotransplantation in Children
- 8. Islet Auto-Transplantation: Indication beyond Chronic Pancreatitis
Section III. Outcomes
- 9. Postoperative Care and Prevention and Treatment of Complications Following Total Pancreatectomy with Islet Cell Autotransplantation
- 10. Metabolic Outcomes after Total Pancreatectomy Followed by Islet Autotransplantation (TPIAT): Mixed Blessings
- 11. Long-term Results of TP/IAT
PART B. BIOENGINEERING AND REGENERATION OF THE ENDOCRINE PANCREAS
Section I. Pancreas Development and Regeneration
- 12. Embryonic Development of the Endocrine Pancreas
- 13. Human pancreatic progenitors
- 14. Strategies to Promote Beta Cell Replication and Regeneration
- 15. Diet as a therapeutic approach to diabetes management and pancreas regeneration
- 16. The Benefits of Metabolic/Bariatric Surgery on Diabetes Mellitus
Section II. Scaffolds for Endocrine Pancreas Bioengineering
- 17. ECM-Based Scaffolds for Pancreas Bioengineering
- 18. Plasma Scaffolds for Islet Transplantation
- 19. Biologic resorbable scaffold for tissue engineering the endocrine pancreas: Clinical experience of Islet Transplantation on the Omentum
- 20. Endothelialized Collagen Modules for Islet Tissue Engineering
Section III. Islet Encapsulation
- 21. Conformal Coating
- 22. Co-Encapsulation of ECM Proteins to Enhance Pancreatic Islet Cell Function
- 23. Co-encapsulation of mesenchymal stromal cells to enhance islet function
- 24. Silk-based Encapsulation Materials to Enhance Pancreatic Cell Functions
- 25. Cell Pouch Devices
Section IV. Stem Cells to Generate Insulin Producing Cells
- 26. Pancreas progenitors
- 27. Human embryonic stem cells (hESC) as a source of insulin producing cells
- 28. Human induced pluripotent stem cells (iPSC) as a source of insulin producing cells
- 29. Ductal cell reprograming to insulin-producing cells as a potential beta cell replacement source for islet auto-transplant recipients
- 30. Synthetic Biology Technologies for Beta Cell Generation
Section V. Animal-based Platforms for Pancreas Bioengineering
- 31. Xenotransplantation of the Endocrine Pancreas
- 32. Interspecies Blastocyst Complementation
Section VI. Tissue Engineering Technologies Applied to Beta Cell Replacement
- 33. Bioengineering, biomaterials and Beta Cell Replacement therapy
- 34. Subcutaneous islet transplantation using tissue-engineered sheets
Section VII. Regulation and Funding
- 35. Regulation for Regenerative Medicine Based Therapies
- 36. Catalyzing beta cell replacement research to achieve insulin independence in Type 1 Diabetes: Goals and Priorities
- 37. Regenerative Medicine Technologies Applied to Beta Cell Replacement: The Industry Perspective
Section VIII: Conclusive Remarks
- 38. Pancreas Whole Organ Engineering
- 39. Ethical Aspects of Transplantation, Bioengineering and Regeneration of the Endocrine Pancreas
