Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas


ORLANDO et al.
Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas Volume 1
890 Seiten, 1. Auflage, 2019

Features: Provides comprehensive and cutting-edge knowledge of whole pancreas and islet transplantation Includes sections that address donor selection, immunosuppression, complications, allograft pathology, and more Offers an update on the progress of regenerative medicine research aimed at beta cells replacement in the treatment of diabetes Table Of Contents:PART A. WHOLE PANCREAS ALLO-TRANSPLANTATION Section I. Introduction 1. History of Pancreas Transplantation 2. How to build a Pancreas Transplant Program 3. Pathophysiology of Diabetes 4. Epidemiology of Diabetes Mellitus Section II. The Donor 5. Pancreas Donor Selection 6. Deceased Donor Pancreas Procurement 7. Surgical Techniques for Living Donor Pancreas Transplantation 8. Pancreas Preservation 9. Pancreas Graft Back-Table Surgery Technique Section III. The Recipient 10. Pancreas Transplant Alone 11. Pancreas After Kidney Transplantation 12. Simultaneous Pancreas-Kidney Transplantation 13. Surgical Techniques for Deceased Donor Pancreas Transplantation 14. Robotic Pancreas Transplantation 15. Pancreas Transplantation in the setting of multivisceral transplantation 16. Imaging in pancreas transplantation 17. Post-Operative Care of the Pancreas Transplanted Patient 18. Immunosuppression for Pancreas Allo-Transplantation Section IV. Complications after Pancreas Allo-Transplantation 19. Infectious Complications after Pancreas Allo-Transplantation 20. Medical Complications after Pancreas Transplantation 21. Technical Complications of Pancreas Allo-Transplantation 22. Rejection After Pancreas Transplantation Section V. Natural History 23. Reversal of Secondary Complications of Type 1 Diabetes (Nephropathy, Neuropathy, Retinopathy, and Cardiopathy) 24. Recurrence of Type 1 Diabetes following Simultaneous Pancreas-Kidney Transplantation 25. Pathological Evaluation of Whole Pancreas Transplants 26. Failure of the Pancreas Allograft 27. Pancreas Retransplantation Section VI: State of the Art of Pancreas Transplantation 28. The Current State of Pancreas Transplantation in the USA - A Registry Report 29. Trends in Pancreas Transplantation in the United States 30. Experimental pancreas transplantation 31. Pancreas Transplantation: Current Issues, Unmet Needs and Future Perspectives PART B. ISLET ALLO-TRANSPLANTATION Section I. Introduction and Indications 32. Treatment of Type 1 Diabetes Complicated by Problematic Hypoglycemia 33. Eligibility of Patients with Type 1 Diabetes for Islet Transplantation Alone 34. Islet versus Pancreas Transplantation in Nonuremic Patients with Type 1 Diabetes 35. Simultaneous Islet-Kidney (SIK) and Islet After Kidney Transplantation (IAK) 36. Pancreatic islet transplantation in cystic fibrosis: lung and islet transplantation 37. Combined Liver and Islet Transplantation in Hepatogenous Diabetes, Cluster Exenteration and Cirrhosis with Type 1 Diabetes Section II. Donor Selection 38. Evolving approaches to organ allocation for whole pancreas versus islet transplantation 39. Living donors 40. Pancreatic Islet Isolation from Donation After Circulatory Death Pancreas Section III. Islet Isolation 41. Factors Related to Successful Clinical Islet Isolation 42. Pancreas and Islet Preservation 43. Collagenases in Pancreatic Islet Isolation 44. Predicting the Function of Islets after Transplantation Section IV. Outcomes after Allogenic Pancreatic Islet 45. Metabolic and Endocrine Evaluation of Islet Transplant Function 46. Procedure-Related and Medical Complications In and After Intraportal Islet Transplantation 47. Secondary Complications of Diabetes Section V. Current Clinical Results 48. Treating diabetes with islet transplantation: lessons learnt from the Nordic network for clinical islet transplantation 49. UK's nationally funded integrated islet transplant program 50. Type 1 Diabetes transplanted with allogenic islets within the Swiss-French GRAGIL Network 51. Primary graft function and long-term outcome of islet allotransplantation: the Lille experience 52. Treating diabetes with islet transplantation: Lessons from the Milan experience 53. Treating Diabetes with Islet Transplantation: Lessons from the University of Miami 54. Treating Diabetes with Islet Cell Transplantation: Lessons from the Edmonton Experience Section VI. Monitoring of Allogeneic Islet Grafts 55. Immune monitoring of allogenic islets 56. Markers for ?eta Cell Loss 57. In Vivo Quality Control of Human Islets in the Immunodeficient Mouse to Predict Islet Function in Man: a retrospective study in 87 clinical transplants Section VII. Immunomodulatory Technologies Applied to Islet Transplantation 58. Progress toward islet transplantation tolerance 59. Anti-inflammatory Strategies to Enhance Islet Engraftment and Survival 60. Islet Immunoisolation by Macroencapsulation 61. Islet Immunoisolation by Microencapsulation 62. Recurrence of Type 1 Diabetes After Beta Cell Replacement Section VIII. Cellular Therapies in Preclinical and Clinical Islet Transplantation 63. T regulatory cell therapy in preclinical and clinical pancreatic islet transplantation 64. Cellular Therapies in Preclinical Clinical Islet Transplantation: Mesenchymal Stem Cells 65. Alternative transplantation sites for islet transplantation
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