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- Explains thyroid hormone alteration in heart failure
- Discusses the topic of thyroid and heart failure, from experimental to clinical settings
- Presents a translational approach for clinics, with potential new strategies for treatment of heart failure
In recent years, several scientific papers have highlighted the role of the thyroid system in cardioprotection, and several clinical studies – including multicenter studies – have identified the role of thyroid hormones (TH) in the development and progression of cardiovascular disease, making an update of TH and heart relationship both necessary and timely. This second edition of Thyroid and Heart failure provides a careful and updated review of the experimental, clinical and epidemiological results in the field of TH and heart failure, with a particular focus on the translational - bench to bedside - significance of the obtained results. It discusses topics such as the molecular, structural, functional, cellular and histological cardiac changes; the reversibility of these changes with TH replacement therapy; the systemic effects – kidney, hormonal pathways systems, brain, muscle, etc – of altered TH metabolism in HF, as well as the clinical and prognostic implications. The section devoted to the potential therapeutic treatments has been expanded. Thanks to its translational approach to this highly complex subject, the book will be of interest to a broad readership, including cardiologists, endocrinologists and internists. Table of ContentsHeart and Thyroid: Historical and Basic Aspects- Thyroid and the Heart: A Historical Perspective
- Physiological Role of Thyroid Hormone in the Developing and Mature Heart
- Thyroid Hormone Signaling Mechanisms in the Heart and Vasculature
Cardiac Metabolism and Function in Thyroid Disorders- Cardiac Metabolic Changes in Altered Thyroid States
- Diastolic and Systolic Dysfunction of the Heart and Thyroid Hormone Abnormalities
Thyroid System in CV Diseases in Experimental Models- TH Metabolism in Ischemia/Reperfusion Models
- Thyroid Hormone Deiodinative Pathways in the Normal and Failing Heart
- TH Metabolism and Active TH Metabolites in the Heart
- Thyroid Hormone, Mitochondrial Function and Cardioprotection
- Thyroid Hormone and Vascular Remodeling in Heart
- Physiological and Pathological Cardiac Remodeling in Altered Thyroid Hormone States
- Thyroid Hormone and Cardiac Repair
- The Role of Thyroid Hormone Receptor α1 in Cardiac Repair
- The Thyroid-Oxidative Stress Axis in Heart Failure
- Thyroid Genetics and the Cardiovascular System
Heart and Thyroid in Clinics- Thyroid and Cardiovascular Risk
- Heart in Overt and Subclinical Hypothyroidism
- Blood Pressure in Thyroid Dysfunction
- Thyroid, Lipids, and Risk of Atherosclerosis
- Arrhythmias in Thyroid Disorders
- Thyroid Hormone Abnormalities in Myocardial Infarction
- Thyroid, Heart Failure, and Neuroendocrine Activation
- Heart Drugs and Influences on TH Metabolism
- Thyroid Dysfunction and Cardiovascular Disease in Chronic Kidney Disease
- Thyroid Hormones, Brain, and Heart
TH Treatment in Cardiac Disorders: Current and New Perspectives- Modalities of Thyroid Hormone Administration and Correlates Between Blood and Tissue Levels
- TH Treatment in Patients with Cardiac Disorders: General Aspects and Rationale
- Thyroid Hormone Treatment in Acute Myocardial Infarction
- TH Treatment in HF
- Thyroid Hormone Treatment in Heart Surgery and Heart Transplantation
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