- Presents the latest research concepts and emerging technologies
- Written by leading experts
- Provides an overview of the fundamentals of regenerative medicine
This book discusses the current research concepts and the emerging technologies in the field of stem cells and tissue engineering. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner.
Divided into five parts, the book opens with a description of the elements of regenerative medicine including definitions, basic principles of soft and bone tissue regeneration, biomaterials and scaffolds. Current research concepts are explored in the second part of this book, for example mechanotransduction and the utility of extracellular vesicles. In the third part, the editors present the emerging technologies and highlight the novel perspectives on bionic reconstruction and biomimetics in surgery and regenerative medicine. Part four deals with translational aspects including practical information on moving scientific findings from bench to bedside. The final part then describes in detail applications in clinical plastic surgery.
Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties.
Table of ContentsPart I - ELEMENTS OF REGENERATIVE MEDICINE- 1. Definitions
- 2. History of Regenerative Medicine
- 3. Basic Principles and Current Approach for Soft Tissue Regeneration
- 4. Sophisticated Biocomposite Scaffolds from Renewable Biomaterials for Bone Tissue Engineering
Part II - RESEARCH CONCEPTS- 5. Mechanotransduction in wound healing and scar formation
- 6. Stromal Cell-Derived Factor1 (SDF-1) Signaling and Tissue Homeostasis
- 7. Stem Cell Differentiation Directed by Material and Mechanical Cues
- 8. Bacteriophages: a New (Yet Old) Weapon against Infections
- 9. Bacteriophages as Biocontrol Agents of Biofilm Infections Associated with Abiotic Prosthetic Devices
- 10. Extracellular vesicles derived from Mesenchymal Stem/Stromal Cells: Current Approaches to Enhance Their Release and Therapeutic Potential
- 11. Anti-Biofilm Activity of Viruses, Bacteria, Fungi and Lichens: Mechanisms and Impact on Clinical Practice
Part III - EMERGING TECHNOLOGIES- 12. Bionic Reconstruction: The New Frontier
- 13. Carbohydrates in Regenerative Medicine: From Scaffolds to Cell Fate Modulators
- 14. Biomimetics: A New Abstraction for Bone Implant Design
- 15. The Role of Microbiota in Skin Regeneration
- 16. Erythropoietin: An Innovative Therapeutic Approach in Thermal Trauma
- 17. Targeting C-Reactive Protein in Inflammatory Disease
- 18. Stem Cell Therapies for Tissue Regeneration and Wound Healing: Strategies to Enhance Therapeutic Effectiveness
- 19. Iron Chelators & HIF-1α: A new Frontier for Skin Rejuvenation
Part IV - TRANSLATIONAL ASPECTS- 20. How to Overcome the Valley of Death from Basic Science to Clinical Trials
- 21. Moving Your Results from Bench to Bedside: Protecting Scientific Findings
- 22. The Regulatory Landscape of Cell- and Tissue-Based Regenerative Medicine: Current Challenges and Emerging Issues
- 23. Translational Challenges in Soft Tissue Regeneration
- 24. Bone Tissue Engineering Challenges in Craniofacial Reconstructive Surgeries
- 25. Translational Challenges: Lymph Node Tissue Engineering
- 26. Implementing Tissue Engineering and Regenerative Medicine Solutions in Silicone Implants
Part V - REGENERATIVE PLASTIC SURGERY- 27. Microdeformational Wound Therapy
- 28. Clinical Treatment of Hypertrophic Scars
- 29. Tissue Engineering and Regenerative Medicine in Oral and Maxillofacial Surgery: The Most Important Clinical Applications of Mesenchymal Stem Cells
- 30. Reconstruction of Post-Traumatic Maxillary Ridges Using a Radial Forearm Free Flap and Allogeneic Tissue Engineered Bone Grafts
- 31. Postoperative Complications of Mandibular Fracture Management
- 32. Use of Porcine Urinary Bladder Matrix (UBM-ECM) in the Head and Neck Region
- 33. Advances in Facial Nerve Paralysis: Surgical Innovation, Tissue Engineering, and Emerging Technology
- 34. Management of Capsular Contracture: Non- Surgical and Surgical Options
- 35. Soft Tissue Reconstruction of the Lower Limb
