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- Comprehensively presents the state-of-the-art in mitochondrial medicine
- Pursues a translational approach, from basic science to clinical practice
- Written by the world’s foremost mitochondrial researchers
- Highlights the latest advances in the field of mitochondrial medicine
This book will help readers navigate the complexity of mitochondrial disorders, by addressing the role of mitochondrial dysfunction and the complex pathophysiological mechanisms associated with a growing number of illnesses, not only of neurological interest. Further, it provides updated concepts on genotype-phenotype correlations, clinical syndromes, diagnostic algorithms and therapies. Written by the world’s foremost mitochondrial researchers, the book comprehensively presents the state-of-the-art in mitochondrial medicine, making it of interest to a wide variety of specialists, including neurologists, geneticists, internists and biologists. Table of Contents- Mitochondrial Medicine: A Historical Point of View
- Mitochondria: Muscle Morphology
- Mitochondrial Disease Genetics
- Epidemiology of Mitochondrial Disease
- Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes (MELAS)
- Myoclonus Epilepsy with Ragged-Red Fibers (MERRF)
- Diseases of DNA Polymerase Gamma
- Mitochondrial Optic Neuropathies
- Mitochondrial Myopathies, Chronic Progressive External Ophthalmoparesis, and Kearns-Sayre Syndrome
- Leigh Syndrome
- Coenzyme Q10 Deficiency
- Mitochondrial Depletion Syndromes
- Mitochondrial Neurogastrointestinal Encephalomyopathy Disease (MNGIE)
- Mitochondrial Neurodegenerative Disorders I: Parkinsonism and Cognitive Deficits
- Mitochondrial Neurodegenerative Disorders II: Ataxia, Dystonia and Leukodystrophies
- Mitochondrial Heart Involvement
- Diagnostic Approach to Mitochondrial Diseases
- Neuroimaging Findings in Primary Mitochondrial Cytopathies
- Outcome Measures and Quality of Life in Mitochondrial Diseases
- The Pathophysiology of Exercise and Effect of Training in Mitochondrial Myopathies
- Mitochondrial Symptomatic Treatments
- Experimental Therapies
- Reproductive Options for Women with Mitochondrial Disease
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