- The first comprehensive book in the field of small fiber neuropathy
- Introduces various small fiber neuropathy related diseases
- Provides thorough information important for diagnosis, research, and therapy of small fiber neuropathy
This book provides comprehensive coverage of small fiber neuropathy (SFN), from diagnosis to therapy. It focuses on nerve degeneration and neuropathic pain, and their underlying pathology, physiology, psychophysics, genetics and imaging.
In particular, this book describes and discusses the major advances in diagnostic techniques for assessing SFN. These include skin biopsy, evoked potentials, quantitative sensory testing and functional studies, as biomarkers of SFN.
SFN is a common peripheral nerve disorder, but was often overlooked due to a lack of objective and specific diagnostic tests for the assessment of small nerve fibers. These fibers mediate thermal sensation, pain detection (nociception), and autonomic regulation. Major symptoms of SFN include neuropathic pain, impaired sensation and autonomic dysfunction. Neuropathic pain poses a diagnostic challenge to clinicians, an essential step for selecting appropriate treatment to relieve suffering.
SFN frequently develops in systemic diseases such as diabetes mellitus, following chemotherapy, infections etc., or presents as a major feature of various genetic neuropathies (e.g. channelopathy and familial amyloidosis). In addition to describing these conditions which lead to SFN, this book also describes related syndromes of neurodegeneration and pain, including fibromyalgia, visceral pain and hypersensitivity.
This definitive book covers both clinical aspects and research progress, which provides in-depth and up-to-date information on SFN. It would be immensely useful for clinicians, neurologists, neuroscientists, diabetologists, and pain specialists.
Table of Contents- Overview of small fiber neuropathy and clinical aspects of small fiber neuropathy.-
- Pathology of small fiber neuropathy: skin biopsy for nociceptive nerve.-
- Neurophysiology: evoked potential.-
- Psychophysics.-
- Autonomic examinations and nerve pathology.-
- Diabetic neuropathy, metabolic syndrome.-
- Genetic small fiber neuropathy.-
- Amyloid neuropathy.-
- Small fiber involvment in conventional large fiber neuropathy.-
- Vasculitis and autoimmune disorders, infectious neuropathy.-
- Pain syndromes.-
- Visceral pain and hypersensitivity disorders.-
- Small fiber pathology in neurodegenerative disorders.-
- Neuropathic pain in small fiber neuropathy.-
- Therapy for small fiber neuropathy.
