- A discussion in order to tailor the treatment of diffuse gastric cancer
- Focus on the differentiation between diffuse gastric cancer and gastric cancer in general
- Comprehensive approach, from basic aspects (pathology and genetics) to the most recent diagnostic and therapeutic alternatives
We live in an era of personalized medicine and the knowledge about pathophysiology of diffuse gastric cancer has had many advances. Thus, the role of this work is to clarify what is new from diagnosis to treatment of this disease in order to treat patients in the most tailored manner as possible.
Almost all phase III trials in gastric cancer have been performed without taking in consideration histologic subtypes, i.e. they have disregarded
the differences between diffuse gastric cancer and general gastric cancer. However, the clinical practice reveals that diffuse gastric cancer is a completely distinct disease, with an aggressive course and generally worse prognosis. The loss of cohesion between tumor cells due to the loss of E-cadherin synthesis is the critical point on the oncogenesis of diffuse gastric cancer and is at the root of its marked heredity.
This book intends to give special attention to
Diffuse Gastric Cancer as a particular oncological entity, differentiating it from general gastric cancer, exploring and discussing all its peculiarities, and addressing the basic aspects (pathology and genetics) along with the most recent therapeutic alternatives for this condition.
Table of Contents- Introduction
- Epidemiology
- The role of Endoscopy
- Pathology and Molecular Biology
- Genetic Predisposition and Hereditary Syndromes
- The Role of Surgery
- The Role of Radiotherapy
- The Role of Chemotherapy
