Neuromodulation: Comprehensive Textbook of Principles, Technologies, and Therapies, Second Edition, serves as a comprehensive and in-depth reference textbook covering all aspects of the rapidly growing field of neuromodulation. Since the publication of the first edition seven years ago, there has been an explosion of knowledge in neuromodulation, optogenetics, bioelectronics medicine and brain computer interfacing.
Users will find unique discussions of the fundamental principles of neuromodulation and therapies, and how they are applied to the brain, spinal cord, peripheral nerves, autonomic nerves and various organs. The book focuses on comprehensive coverage of spinal cord stimulation, non-interventional and interventional brain stimulation, peripheral nerve stimulation, and the emerging fields of neuromodulation, including optogenetics and bioelectronics medicine.
Features:- Provides a comprehensive reference that covers all aspects of the growing field of neuromodulation
- Written by international, leading authorities in their respective fields of neuromodulation, pain management, functional neurosurgery and biomedical engineering
- Includes new chapters on optogenetics, bioelectronics medicine and brain computer interfacing
Table of ContentsVolume 1:
SECTION I: Defining Neuromodulation
- 1. Perspectives on the History of the Neuromodulation Societies
- 2. Psychological Issues and Evaluation for Patients Undergoing Implantable Technology
- 3. Relevant Anatomy of the Nervous System to Neuromodulation (central, peripheral, autonomic-Vagus)
- 4. Clinical Study Designs for Neuromodulation
SECTION II: The Brain Initiative—Implications for a Revolutionary Change in Clinical Medicine via Neuromodulation Technology
- 5. The Brain Initiative—Implications for a Revolutionary Change in Clinical Medicine via Neuromodulation Technology
SECTION III: FUNDAMENTALS AND MECHANISMS OF NEUROMODULATION
- 6. Fundamentals of Electrical Stimulation
- 7. The Safe Delivery of Electrical Currents and Neuromodulation
- 8. The Role of Wave Forms for Electrical Stimulation of the Nervous System
- 9. Neuromodulation and Neuronal Plasticity
- 10. Fundamentals of High Frequency Nerve Conduction Block of the Peripheral Nervous System
- 11. MRI and fMRI for Neuromodulation Vibhor Krishna
- 12. Computational Modeling of Deep Brain Stimulation
- 13. Computational Modeling of Deep Brain Stimulation – Neurotargeting
- 14. Fundamentals of Burst Stimulation of the Spinal Cord and Brain
- 15. Mechanisms of Action of Spinal Cord Stimulation for Pain (Traditional, Dorsal Root Spinal Stimulation, kHz frequency stimulation
- 16. Fundamentals and Mechanisms of Dorsal Root Ganglion (DRG) Stimulation
- 17. Mechanisms of Action of Deep Brain Stimulation
- 18. Mechanisms of Action of Vagal Nerve Stimulation
- 19. Mechanisms of Action of Sacral Nerve Stimulation for Disorders of Bladder and bowel
SECTION IV: TECHNOLOGY AND DEVICES
- 20. Electrodes for Recording and Stimulating the Peripheral Neural Interface
- 21. Implantable Neural Stimulators: Powering, Control and Packaging
- 22. Microstimulators
- 23. Designing Neuromodulation Systems For Feedback Control
- 24. MRI Safety and Neuromodulation Systems
SECTION V: BRAIN, COMPUTER AND MACHINE INTERFACING
- 25. Brain Computer Interfaces: Why Not Better?
- 26. Non-Invasive BCI
- 27. Invasive BCI
- 28. Prospects for a robust cortical recording interface
- 29. Brain Machine Interfacing—Signal Processing, and extraction of signals
SECTION VI: EMERGING TECHNOLOGIES AND TECHNIQUES
- 30. Gene-Based Neuromodulation
- 31. Focused Ultrasound
- 32. Implanted Sensors in Neuromodulation via Electrical Stimulation
- 33. Neurogaming
- 34. The Use of New Surgical Technologies for Deep Brain Stimulation (ultrasound, atlases, MRI)
- 35. Neuromodulation Using Optogenetics and Related Technologies
SECTION VII: SURGICAL PROCEDURES AND TECHNIQUES
- 36. Deep Brain Stimulation: Surgical Technique
- 37. Spinal Cord Stimulation: Placement of Surgical Leads via Laminotomy Techniques and Benefits
- 38. Subcutaneous Peripheral Nerve Field Stimulation for Intractable Pain
- 39. Surgical Placement of Leads for Occipital Nerve Stimulation
- 40. Intrathecal Medication Delivery System Implantation
- 41. Neuroprosthetic Surgical Strategies for Neuromuscular Stimulation
- 42. The Surgical Technique of Vagus Nerve Stimulator Implantation
VOLUME 2 SECTION VIII: NEUROMODULATION FOR PAIN CONTROL
SECTION VIII A: SPINAL CORD STIMULATION FOR PAIN CONTROL
- 43. Physiology and Pathophysiology of Chronic Pain
- 44. Management Strategies for Chronic Pain
- 45. History of Spinal Cord Stimulation
- 46. Functional Magnetic Resonance Imaging in the Neuromodulation of Pain
- 47. The Development of Algorithms for Pain Care including Neuromodulation Therapies: Introducing the SAFE Principle
- 48. Neurostimulation for the Treatment of Complex Regional Pain Syndrome
- 49. Spinal Cord Stimulation for Peripheral Neuropathic Pain
- 50. Spinal Cord Stimulation for the Treatment of Low Back Pain
- 51. Spinal Cord Stimulations: Complications and Management
- 52. Clinical Aspects of Burst stimulation for Pain Control
- 53. DRG stimulation for Pain Control
- 54. High Frequency Stimulation of the Spinal Cord for Pain Control
- 55. A Review of Spinal Cord Stimulation Cost Studies
SECTION VIII B: PERIPHERAL NERVE STIMULATION FOR PAIN CONTROL INTRODUCTION: PERIPHERAL NERVE STIMULATION FOR PAIN CONTROL
- 56. Anatomy and Physiology Related to Peripheral Nerve Stimulation
- 57. Peripheral Nerve Stimulation for Pain Suppression
- 58. Peripheral Nerve Stimulation for Facial Pain
- 59. Combined Spinal Cord Stimulation and Peripheral Field Stimulation for the Treatment of Chronic Back and Neck Pain
- 60. Percutaneous Peripheral Nerve Stimulation for the Management of Acute Post-Operative Pain
- 61. Peripheral Nerve Field Stimulation for intractable pain
- 62. Occipital Neurostimulation for Treatment of Intractable Headache Syndromes
- 63. Neurostimulation for Headaches—Sphenopalatine Ganglion Stimulation
SECTION VIII C: INTRATHECAL THERAPIES FOR PAIN CONTROL AND THE CONTROL OF SPASTICITY
- 64. Relevant Anatomy for Spinal Delivery
- 65. Evolution of the Spinal Delivery of Opiate Analgesics
- 66. Pharmacology of Intrathecal Therapy
- 67. Cerebrospinal Fluid Dynamics and Intrathecal Delivery
- 68. Exploring Non-Opioid Analgesic Agents for Intrathecal Use
- 69. New Molecules for Intrathecal Delivery for Pain Control
- 70. The Development of Guidelines for Intrathecal Therapies for Pain Control: History and Present Guidelines
- 71. Compounding Intrathecal Analgesic Agents
- 72. Intrathecal Baclofen for Control of Spasticity
SECTION VIII D: INTRACRANIAL PROCEDURES FOR CHRONIC PAIN
- 73. Deep Brain Stimulation for Pain
SECTION IX: NEUROMODULATION FOR MOVEMENT DISORDERS
- 74. Deep Brain Stimulation for Parkinson’s Disease76. Deep Brain Stimulation for Torsion Dystonia
- 77. Deep Brain Stimulation for Tourette Syndrome
- 78. Surgical Management of Hemifacial Spasm and Meige Syndrome
- 79. Deep Brain Stimulation of the Pedunculopontine Tegmental Nucleus improves static balance in Parkinson’s Disease
- 80. Infusion Therapy for Movement Disorders
SECTION X: NEUROSTIMULATION FOR EPILEPSY
- 81. Epilepsy: Anatomy, Physiology, Pathophysiology, and Disorders
- 82. Vagus Nerve Stimulation for Epilepsy
- 83. Deep Brain Stimulation for Epilepsy
- 84. Closed loop Responsive stimulation for Epilepsy
SECTION XI: NEUROMODULATION FOR BEHAVIORAL AND COGNITIVE DISORDERS
- 85. Electrical Brain Stimulation for Treatment-Resistant Obsessive–Compulsive Disorder
- 86. High-Intensity Focused Ultrasound Surgery for the Treatment of Obsessive-Compulsive Disorder
- 87. Deep Brain Stimulation for Highly Refractory Depression
- 88. Neuromodulation for Anorexia
- 89. Deep Brain Stimulation for Alcoholism
- 90. Surgical Treatment for Refractory Drug Addictions
- 91. Subgenual Cingulate Deep Brain Stimulation for Treatment-Resistant Depression
- 92. Cortical Stimulation for Depression
VOLUME 3
SECTION XII: NEUROMODULATION FOR FUNCTIONAL RESTORATION
- 93. The History of Neuromuscular Electrical Stimulation
- 94. Stimulation for Return of Function after Stroke
- 95. Invasive Neurostimulation for Post Stroke Motor Recovery
- 96. Stimulation for Return of Upper Extremity Function
- 97. Lower Extgremity Motor System Neuroprostheses
- 98. Neuromodulation of the Spinal Cord for Movement Restoration
- 99. A brief history of the cochlear implant and related treatments
- 100. Stimulation for the Return of Hearing
- 101. The Development of Visual Prosthetic Devices to Restore Vision to the Blind
- 102. Neuromodulation for Treatment of Dry Eye
- 103. Restoration of Tactile Sensation Dustin Tyler
SECTION XIII: NEUROMODULATION FOR ORGAN SYSTEMS
SECTION XIII A: NEUROMODULATION FOR CARDIOVASCULAR DISORDERS
- 104. Autonomic control of the heart
- 105. Spinal Cord Stimulation for Peripheral Vascular Disorders
- 106. Neuromodulation for Refractory Angina and Heart Failure
- 107. Baroreceptor activation for hypertension and heart failure
SECTION XIII B: NEUROMODULATION FOR PULMONARY DISORDERS
- 108. Upper Airway Neurostimulation to Treat Obstructive Sleep Apnea
- 109. A Neural Prosthesis for Obstructive Sleep Apnea
- 110. Transvenous phrenic nerve stimulation for central sleep Apnea
- 111. Neurostimulation for Asthma
- 112. Stimulation for Inspiration
- 113. Stimulation for Cough
SECTION XIII C: NEUROMODULATION FOR GASTROINTESTINAL DISORDERS
- 114. Neural Control of the GI System
- 115. Spinal Cord Stimulation for Gastrointestinal Painful Disorders
- 116. Emerging Gastric Stimulation for Dysmotility Disorders and Obesity
- 117. Intestinal Electrical Stimulation: Methodologies, Effects, Mechanisms, and Applications
- 118. Neuromodulation for nausea and vomiting in adult patients
- 119. Neuromodulation for GI Dysmotility in pediatric patients
- 120. Colonic electrical stimulation for constipation
SECTION XIII D: NEUROMODULATION FOR UROGENITAL DISORDERS
- 121. Neurophysiology and Neuroanatomy of the Genitourinary Organs
- 122. Sacral Nerve Stimulation
- 123. Sacral Nerve Root Stimulation for Painful Bladder Syndrome/Interstitial Cystitis
- 124. Restoration of Urinary and Bowel Control
SECTION XIV: Neuromodulation for endocrine, immune, and inflammatory disorders
- 125. Vagal nerve stimulation and control of anti-inflammatory pathways
- 126. Activation of the Inflammatory Reflex in Rheumatoid Arthritis and Inflammatory Bowel Disease; Preclinical Evidence
- 127. Bioelectronic Therapy for the Treatment of Rheumatoid Arthritis and Inflammatory Bowel Disease
- 128. Vagal Nerve Stimulation versus Sacral Nerve Stimulation for Control of Inflammation
- 129. Autonomic regulation therapy (ART) for disorders of the heart
- 130. The Neural Tourniquet
- 131. Neural decoding for diagnostics and restoration of motor function
- 132. The Role of Vagus Nerve Stimulation for the Treatment of Central and Peripheral Pain Disorders and Related Co-morbid Somatoform Conditions
- 133. Insulin Resistance, Glucose Metabolism, Inflammation and the Role of Neuromodulation as a Therapy for Type-2 Diabetes
SECTION XV: NON INVASIVE NEUROMODULATION
- 134. Transcranial Magnetic Stimulation
- 135. Transcranial Direct Current Stimulation
- 136. Transcranial Pulse Current Stimulation
- 137. Novel Methods of Transcranial Stimulation: Electrosonic Stimulation
- 138. Optimization of Non-Invasive Brain Stimulation
- 139. Transcranial Direct Current Stimulation for Fatigue and Attentional Disorders
SECTION XVI: THE BUSINESS END OF NEUROMODULATION
- 140. Challenges in Moving Toward Product Development: from the Perspective of Neuromodulation Companies
- 141. Neuromodulation, the field from an industry perspective in 2016
- 142. Neuromodulation: Regulatory Considerations
- 143. Reimbursement for neuromodulation therapies and technologies
- 144. Perspectives on How to Build a Neuromodulation Practice
