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- Concisely describes biophysics-based approaches used in quantitative medical imaging
- Clarifies the diagnostic potential of these approaches
- Elucidates the relationships between tissue properties, imaging technology, and medical applications
This book provides a selection of essential knowledge on the image-based quantification of biophysical parameters for the purpose of clinical diagnosis. The authors regard clinical imaging scanners as physical measurement systems capable of quantifying intrinsic parameters for depiction of the constitution and biophysical properties of in vivo tissue. On the one hand, this approach supports the development of new methods of imaging highly reproducible, system-independent, and quantitative biomarkers, and these methods receive detailed attention in the book. On the other hand, the reader will also gain a deeper understanding of how physical tissue properties interact with the generation of signals in medical imaging, opening new windows on the intricate and fascinating relationship between the structure and function of living tissues. The book will be of interest to all who recognize the limitations of basing clinical diagnosis primarily on visual inspection of images and who wish to learn more about the diagnostic potential of quantitative and biophysics-based medical imaging markers and the challenges that the paucity of such markers poses for next-generation imaging technologies. Table of Contents Biological and Physical Fundamentals - Mathematical Modeling of Blood Flow in the Cardiovascular System
Alfonso Caiazzo, Irene E. Vignon-Clementel - A Biphasic Poroelasticity Model for Soft Tissue
Sebastian Hirsch - Physical Properties of Single Cells and Collective Behavior
Hans Kubitschke, Erik W. Morawetz, Josef A. Käs, Jörg Schnauß - The Extracellular Matrix as a Target for Biophysical and Molecular Magnetic Resonance Imaging
Angela Ariza de Schellenberger, Judith Bergs, Ingolf Sack, Matthias Taupitz
Medical Imaging Technologies - Mathematical Methods in Medical Image Processing
Gitta Kutyniok, Jackie Ma, Maximilian März - Acceleration Strategies for Data Sampling in MRI
Christoph Kolbitsch, Tobias Schaeffter - 4D Flow MRI
Sebastian Schmitter, Susanne Schnell - CEST MRI
Martin Kunth, Leif Schröder - Innovative PET and SPECT Tracers
Ulrich Abram - Methods and Approaches in Ultrasound Elastography
Heiko Tzschätzsch - Photoacoustic Imaging: Principles and Applications
Jan Laufer - Fundamentals of X-Ray Computed Tomography: Acquisition and Reconstruction
Marc Dewey, Marc Kachelrieß
Applications - Quantification of Myocardial Effective Transverse Relaxation Time with Magnetic Resonance at 7.0 Tesla for a Better Understanding of Myocardial (Patho)physiology
Till Huelnhagen, Teresa Serradas-Duarte, Fabian Hezel, Katharina Paul, Thoralf Niendorf - Extracellular Matrix-Specific Molecular MR Imaging Probes for the Assessment of Aortic Aneurysms
Julia Brangsch, Carolin Reimann, Marcus R. Makowski - Diffusion-Based MRI: Imaging Basics and Clinical Applications
Michael Scheel - Quantification of Functional Heterogeneities in Tumors by PET Imaging
Winfried Brenner, Florian Wedel, Janet F. Eary - Tumor Characterization by Ultrasound Elastography and Contrast-Enhanced Ultrasound
Thomas Fischer, Anke Thomas, Dirk-André Clevert - Sensitivity of Tissue Shear Stiffness to Pressure and Perfusion in Health and Disease
Jing Guo, Florian Dittmann, Jürgen Braun - Radionuclide Imaging of Cerebral Blood Flow
Ralph Buchert - Cardiac Perfusion MRI
Amedeo Chiribiri - Myocardial Perfusion Assessment by 3D and 4D Computed Tomography
Marc Dewey, Marc Kachelrieß
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