Chordomas and Chondrosarcomas of the Skull Base and Spine, Second Edition, is a major reference and guide for neurosurgeons, medical oncologists, neuroscientists, orthopedic surgeons, head and neck surgeons and radiation oncologists that treat patients and research chordomas and chondrosarcomas of the axial skeleton. This book is the unique result of the collaboration of multidisciplinary specialists from a wide variety of fields (neurological sciences, medical oncology, molecular biology, orthopedics and radiation oncology), offering the most relevant information about chordomas and chondrosarcomas of the axial skeleton from each of these fields condensed into one single volume.
It contains new medical knowledge and scientific advances regarding the treatment of these types of tumors. Additionally, the book includes chapters written by the Chordoma Foundation and Sarcoma Foundation of America, providing the most valuable information and support for patients and their relatives.
Features:- Presents an up-to-date, comprehensive resource that details chordomas and chondrosarcomas from a multidisciplinary approach
- Edited by the leading researchers in brain and skull base tumors
- Includes chapters written by the Chordoma Foundation and Sarcoma Foundation of America
Table of Contents:SECTION I: EMBRYOLOGY, PATHOLOGY AND MOLECULAR BIOLOGY
- 1. Embryology of the Skull Base and Vertebral Column
- 2. Pathology of Chordoma and Chondrosarcoma of the Axial Skeleton
- 3. Molecular Drivers in Chordoma
- 4. Molecular Drivers in Chondrosarcoma
SECTION II. DEMOGRAPHICS, PRESENTATION AND DIAGNOSIS
- 5. Demographics, Presentation, and Diagnosis
- 6. Differential Diagnosis of Clival and Spinal Tumors
- 7. Imaging Cranial Base Chordoma and Chondrosarcoma
- 8. Imaging Chordoma and Chondrosarcoma of the Vertebrae and Sacrum
SECTION III: SURGERY OF SKULL BASE TUMORS
- 9. Surgical Anatomy of the Skull Base
- 10. Skull Base Tumors: Surgical Considerations
- 11. Midline Subfrontal Approaches: The Transbasal Approach and Extended Modifications to Access the Clivus
- 12. The Endoscopic Endonasal Approach (EEA) to Chordomas and Chondrosarcomas
- 13. Transoral Approaches to Midline Skull Base Tumors
- 14. Chordomas and Chondrosarcomas of the Skull Base: Anterolateral Approaches
- 15. Lateral Approaches
- 16. Subtemporal Preauricular Approach to the Infratemporal Fossa
- 17. Chordomas and Chondrosarcomas of the Skull Base: Transpetrosal Approaches
- 18. Chordomas and Chondrosarcomas of the Skull Base: Retrosigmoid Approaches
- 19. The Extreme Lateral Approach for Chordomas and Chondrosarcomas of the Craniovertebral Junction
- 20. Staged Approaches for Large Skull Base Chordomas and Chondrosarcomas
- 21. Cerebral Revascularization for Skull Base Tumors
- 22. Skull base reconstruction following resection of skull base chordomas and chondrosarcomas
- 23. Stabilization of the Craniocervical Junction Following Resection of Chordomas and Chondrosarcomas of the Skull Base
SECTION IV: SURGERY OF SPINAL AND SACRAL TUMORS
- 24. Chordomas and Chondrosarcomas of the Spine: Pre-operative Planning, Surgical Strategies and Complications Avoidance
- 25. Surgical Management of Chordomas and Chondrosarcomas of the Cervical Spine
- 26. Surgical Management of the Chordomas and Chondrosarcomas of the Thoracic Spine
- 27. Surgical Management of Chordomas and Chondrosarcomas of the Lumbar Spine
- 28. Anatomical Considerations for Resection of Chordomas and Chondrosarcoma of the Sacrum
- 29. Surgical management of sacral chordoma
SECTION V: RADIATION THERAPY OF CHORDOMAS AND CHONDROSARCOMAS
- 30. Fractionated Photon Radiation Therapy for Skull Base Chordomas and Chondrosarcomas
- 31. Stereotactic Radiosurgery for Skull Base Chordomas
- 32. Proton Therapy for Skull Base Chordomas and Chondrosarcomas
- 33. Photon Irradiation for Spinal Chordomas and Chondrosarcomas
- 34. Proton Therapy for Spinal Chordomas and Chondrosarcomas
- 35. Heavy Ion Radiation for Chordomas and Chondrosarcomas
SECTION VI: SPECIAL CONSIDERATIONS
- 36. Chordomas and Chondrosarcomas in Children
- 37. Recurrent Skull Base Chordomas: Role of Surgery
- 38. Systemic Therapies for Locally Recurrent or Metastatic Disease
- 39. Chordomas and Chondrosarcomas of the Axial Skeleton: Emerging Therapies and Future Directions
SECTION VII: PATIENT DIRECTORY
- 40. Prognosis, Survival and Surveillance
- 41. The Chordoma Foundation
- 42. Sarcoma Patient Advocacy: Hope and Help
