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- Equips readers with an up-to-date understanding of the biomedical and neurobiological underpinnings of depression
- Elucidates the factors and interactions underlying individual variation in vulnerability to depression
- Identifies potential treatment targets and causes of treatment resistance
This book, in two volumes, focuses on contemporary issues and dilemmas in relation to depression. The aim is to equip readers with an up-to-date understanding of the clinical and neurobiological underpinnings of depression and their relation to clinical manifestations and the development of more effective treatments. This first volume is devoted specifically to biomedical and neurobiological issues. Detailed information is presented on a wide range of topics, including genetics, molecular and cellular biology, and aspects at the neural circuit and multicellular system levels. Readers will gain a deeper appreciation of the factors and interactions underlying individual variation in responsiveness to stress and vulnerability to depression, as well as a clear understanding of potential treatment targets and causes of treatment resistance based on the latest research. A concluding section considers progress towards precision psychiatry and gender and cultural differences in depression. The companion volume is dedicated to clinical and management issues in depression. Understanding Depression will be an excellent source of information for both researchers and practitioners in the field. Table of ContentsGenetic and Epigenetic Aspects of Depression - Highlights on Pharmacogenetics and Pharmacogenomics in Depression
Chiara Fabbri, Alessandro Serretti - Imaging Genetics Studies on Susceptibility Genes for Major Depressive Disorder, the Present and the Future
Eunsoo Won, Byung Joo Ham, Yong-Ku Kim - Gene-Environment Interactions and Role of Epigenetics in Depression
Eugene Lin, Shih-Jen Tsai - miRNAs As Critical Epigenetic Players in Determining Neurobiological Correlates of Major Depressive Disorder
Bhaskar Roy, Yogesh Dwivedi - The Role of Early Life Stress in HPA Axis and Depression
Mario F. Juruena, Anthony J. Cleare, Allan H. Young
Molecular- and Cellular-Level Aspects of Depression - Complex Role of the Serotonin Receptors in Depression: Implications for Treatment
Meysam Amidfar, Lejla Colic, Martin Walter, Yong-Ku K - Emerging Role of Glutamate Receptors in Pathophysiology of Depression
Kyoung-Sae Na, Yong-Ku Kim - New Perspective on mTOR Pathways: A New Target of Depression
Gislaine Z. Réus, Zuleide M. Ignácio, Helena M. Abelaira, João Quevedo - Biological Markers to Differentiate the Subtypes of Depression
Je-Yeon Yun, Seung-Hwan Lee
Neural Circuit-Level Aspect of Depression - Structural, Functional, and Molecular Neuroimaging in Depression
Kai Zhang, Jing Huang, Jin Feng, Hong Zhang, Mei Tian - Why Do We Need Psychopathology? From the Brain’s Resting State to “Spatiotemporal Psychopathology” of Depression
Georg Northoff - Neuroimaging in Depression: A Tool Toward Individualized Prediction of Treatment Outcome
Boudewijn J. H. B. de Pont, Jeroen A. Van Waarde, Guido A. van Wingen - Cortical–Subcortical Interactions in the Pathophysiology of Depression
Kang Soo Lee, Sang Hyuk Lee - Pathophysiology and Treatment Strategies for Different Types of Depression
Hwa-Young Lee, Yong-Ku Kim - The Effect of Neurostimulation in Depression
Rafael C. R. Freire, Antonio E. Nardi
Multicellular System-Level Aspect of Depression - Chronic Inflammation and Resulting Neuroprogression in Major Depression
Brian E. Leonard - Gut-Microbiota-Brain Axis and Depression
Alper Evrensel, Mehmet Emin Ceylan - Modulating Microglial Activation As a Possible Therapeutic Target for Depression
Mina Sato-Kasai, Takahiro A. Kato, Masahiro Ohgidani, Hideki Horikawa, Yoshito Mizoguchi, Akira Monji et al. - Experimental Animal Models for Depressive Disorders: Relevance to Drug Discovery
Boldizsár Czéh, Ove Wiborg, Eberhard Fuchs - The Use of Animal Models in Defining Antidepressant Response: A Translational Approach
Michel Bourin
Individual-, Age-, Gender-, and Culture-Specific Aspects of Depression - Precision Psychiatry: Personalized Clinical Approach to Depression
Giampaolo Perna, Raffaele Balletta, Charles B. Nemeroff - Risk Factors and Prevention Strategies for Depression in Childhood and Adolescence
Jun Won Kim, Jae-Won Kim - Neurobiology and Risk Factors of Late-Life Depression
Neha Jain, David C. Steffens - Gender Differences in Depression
Seoyoung Yoon, Yong-Ku Kim - An Update on the Epidemiology of Major Depressive Disorder Across Cultures
Joao P. De Aquino, Alicia Londono, André F. Carvalho
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