|
- Summarizes the latest diagnostic performance of non- or semi-invasive tests for endometriosis
- Reviews the key current research and developments of biomarkers in related fields
- Explores the future developments necessary to create a successful non-invasive test for endometriosis
This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine. The value of existing and emerging systems biology technologies for biomarker development is addressed in several chapters on genetics, microarrays, proteomics and metabolomics. Although tests with high sensitivity and acceptable specificity have been developed, sometimes validated in independent populations and seem promising, more research is needed to translate these data into clinical benefit for patients and coordinate efforts internationally to standarize analysis, reports and operating procedures. The gold standard to diagnose endometriosis is currently through laparoscopic inspection with histological confirmation, a surgical procedure with rare but significant potential risks for the patients. A non-invasive test for endometriosis would be critical for the early detection of endometriosis of symptomatic women with pelvic pain and/or subfertility with normal ultrasound. This would include nearly all cases of minimal-mild endometriosis, some cases of moderate-severe endometriosis without a clearly visible ovarian endometrioma and cases with pelvic adhesions and/or other pelvic pathology, who might benefit from surgery to improve pelvic pain and/or subfertility. Such a test would also be useful in symptomatic women with ultrasound imaging suspicious for endometriosis, since it may be difficult to differentiate an ovarian endometrioma from other ovarian cysts and since the quality of ultrasound imaging is highly variable worldwide. Table of Contents- Building Translational Research Infrastructure and Access to Expertise for Biomarker Discovery in Cancer
Hall, Jacqueline A. - Biomarkers of Endometrial Cancer
Galazis, Nicholas - Biomarker Development in Chronic Inflammatory Diseases
Katsanos, Aristeidis H. (et al.) - Endometriosis and Diagnostic Delay: The Patient’s Perspective
Apers, Silke (et al.) - Genetic Biomarkers for Endometriosis
Lee, Sang Hong (et al.) - Epidemiological and Clinical Risk Factors for Endometriosis
Farland, Leslie V. (et al.) - Peripheral Blood Biomarkers for Endometriosis
Fassbender, Amelie (et al.) - Biomarkers for Endometriosis in Saliva, Urine, and Peritoneal Fluid
Gueye, Ndeye-Aicha (et al.) - mRNA and miRNA Biomarkers for Endometriosis
Aghajanova, Lusine (et al.) - Proteomic Biomarkers for Endometriosis
Fassbender, Amelie (et al.) - Harmonization of Clinical and Laboratory Data to Improve Biomarker Discovery in Endometriosis: WERF EPHect
Rahmioglu, Nilufer (et al.) - OMICs Studies and Endometriosis Biomarker Identification
Saare, Merli (et al.)
|
