|
A rare form of cancer, chordomas are among the most difficult tumors to treat, requiring highly specialized training and surgical expertise. Although generally slow-growing, chordomas present resection challenges due to their proximity to critical structures including the spinal cord, brainstem, nerves, and arteries. Written by an impressive cadre of internationally-renowned experts, this textbook is the most current, concise, and definitive resource on diagnosis and management of this complex pathology. Acclaimed surgeons from Brazil, Canada, Japan, Turkey, the USA, and the UK are contributors. The book starts with a historical overview, epidemiology, molecular pathogenesis, cytogenetics, local invasion and metastasis, and pathology. A thorough discussion covers diagnostic radiological and radionuclide imaging such as MRI, PET; SPECT, PET-CT, and PET-MRI, and clinical traits of skull base and spinal chordomas as defined by imaging modalities. Subsequent chapters explore decision making including selecting the most optimal techniques, surgical procedures, specialized topics, and new horizons in chordoma treatment. Key Highlights- Anterior and anterolateral approaches to the clivus
- The use of endoscopy and intraoperative assistive technologies
- Midline subfrontal, middle fossa, extended petrosal, and transcondylar approaches
- Craniospinal fusion techniques following resection
- Surgery for spinal chordomas from the cervical to the sacral region
- Special topics such as radiation, proton beam therapy, Gamma-Knife radiosurgery, and pediatric chordomas and chondrosarcomas
This is an essential text for neurosurgeons, orthopedic spine surgeons, otolaryngologists, and radiation oncologists. Read and learn from innovators who have mastered the latest state-of-the-art treatment methodologies for chordomas. Contents Overview:Section I: Definition, History, Demographicsm Pathology, and Pathogenesis - Chapter 1: Historical Aspects
- Chapter 2: The Descriptive Epidemiology of Chordomas
- Chaapter 3: evolutionary origin of the Notochord
- Chapter 4: Molecular Biology of Chordomas
- Chapter 5: Cytogenetics of Chordomas
- Chapter 6: Local Invasion and Metastasis
- Chapter 7: Pathology
- Chapter 8: Experimental Models of Chordomas
Section II: Diagnosis of Chordomas - Chapter 9: Radiologic Findings and Differential Diagnosis of Chordomas at the Skull Base
- chapter 10: Radiologic Findings and Differential Diagnosis of Chordomas in the Spine
- Chapter 11: Molecular Imaging of Chordomas
Section III: Surgical Treatment of Chordomas - Chapter 12: Surgical Decision Making in Chordomas
- Chapter 13: Choice of the Optimal Surgical Approach
- Chapter 14: Anterior Approaches to the Clivus
- Chapter 15 Endoscopic Approaches for Skull Base Chordomas
- Chapter 16: Frontobasal Approaches to the Clivus
- Chapter 17: Cranio-Orbital "Zygomatic" Approaches for Chordomas
- Chapter 18: Epidural Fossa Approach
- Chapter 19: The Extended Petrosal Middle Fossa Approach
- chapter 20: The Transcondylar Approach to the Clivus
- Chapter 21;: Craniovertebral Reconstruction after Chordoma Resection
- Chapter 22: Surgery for Spinal Chordomas
- Chapter 23: Intraoperative Assistive Technologies for Chordoma SurgerySection IV: special Topics in Chordomas
- Chapter 24: chordomas: A Personal Perspective
- Chapter 25: Radiation Treatment for Chordomas
- Chapter 26: Charged Particle Beams in Management of Clival Chordomas
- Chapter 27: Stereotactic Radiosurgery for Chordomas
- Chapter 28: Recurrence in Skull Base Chordomas and its Management
- Chapter 29: Outcome and Quality of Life of Patients with Chordomas
- Chapter 30: Chordomas and Chondrosarcomas in the Pediatric Population
- Chapter 31: Future Prospects in the Treatment of Skull Base
|
