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Features:- Provides an overview of the genetic basis of cardiovascular disease and its risk factors
- Reviews several large population-based studies which indicate that exposure to several environmental factors may increase CVD morbidity and mortality, exploring the plausibility of this association by data from animal studies
- Reflects on future studies to help understanding the role of genes and environmental factors in the development and progression of cardiovascular disease
Table of Contents- Chapter 1. Summary
- Chapter 2. Atherosclerosis and Coronary Artery Disease: From Basics to Genetics
Introduction
Normal Artery Structures
Pathogenesis of Atherosclerosis
Initiation of Atheroma
The Formation of Atherosclerotic Plaque
Clinical Implications of Atherosclerosis
Genetics of Coronary Artery Disease
Atherosclerosis: Therapeutic Options - Chapter 3. The Role of Genetics in Acute Coronary Syndrome
Introduction
Clopidogrel
Prasugrel
Ticagrelor
Genotyping Assays
Cost-effectiveness of Genotyping
Genetic Polymorphisms Related to Aspirin
Future Directions
Summary: Role of Genotyping in Acute Coronary Syndrome - Chapter 4. Global Epidemiology and Incidence of Cardiovascular Disease
Introduction
Global Burden of Disease: Reporting Metrics
Measuring the Global Burden of Cardiovascular Disease
Changes in Total Disease Burden Versus CVD
Global Cardiovascular Mortality
Global Cardiovascular DALY
Risk Factors for CVD Globally
Epidemiological Transition
Aging Population
Ethnicity
Migration
Urbanization
Specific CVD Conditions
Conclusions - Chapter 5. Lifestyle Choices, Risk Factors, and Cardiovascular Disease
Introduction
Dietary Patterns and CV Risk
Physical Activity/Fitness and CV Risk
Obesity and CV Risk
Smoking and CV Risk
Psychological Factors and CV Risk
Conclusion - Chapter 6. The Contribution of Pollutants and Environmental Chemicals in Cardiovascular Disease
Introduction
Air Pollutants
Metal Toxicity
Conclusions - Chapter 7. Genetic Susceptibility to Cardiovascular Diseases: From Mendelian Disorders to Common Variants
Introduction
Genetic Studies: A Methodologic Approach
Genetic Polymorphisms in Cardiovascular Diseases
Genome-Wide Linkage and Association Studies: Leaps Toward Individualized Cardiovascular Medicine?
Conclusions
Glossary - Chapter 8. Role of Conventional Risk Factors in Genetic Susceptibility to Cardiovascular Diseases
The Relationship of Risk Factors and Genetics to Disease
Methods for Assessing Causality
Randomized Controlled Trials
Observational Studies
Genetic Studies and Mendelian Randomization
Blood Lipids
Inflammation
Anthropometric Traits as Risk Factors
Behavioral and Environmental Risk Factors
Limitations of Causal Inference Using Genetics
Conclusions - Chapter 9. Genetic Susceptibility in Biochemical and Physiological Traits
Introduction
Hypertrophic Cardiomyopathy
Channelopathies
Connective Tissue Disorders
Genetic Disorders Leading to Atherosclerosis
Cardiovascular Pharmacogenetics and Pharmacogenomics - Chapter 10. Interactions–Interrelationships Between Genetics and Environmental Factors in Cardiovascular Disease
Introduction
Models of Interaction
Environmental Factors
Interactions Between Genotype, Diet, and Coronary Heart Disease
Interactions Between Alcohol and Coronary Heart Disease
Interaction Between APOE Genotype, Smoking, and Risk of Coronary Heart Disease
Environmental Pollutants, Epigenetics, and Cardiovascular Disease
Drug–Genome Interactions Relevant to Cardiovascular Disease
Gene–Environmental Interactions and Congenital Heart Disease
Conclusions
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