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Bone Metastases from Prostate Cancer

BERTOLDO et al.  

Bone Metastases from Prostate Cancer
Biology, Diagnosis and Management

293 Seiten, 1. Auflage, 2017
63 Abbildungen

  • Equips readers with an excellent understanding of metastasis formation and prognostic factors
  • Explains how best to achieve early diagnosis
  • Presents the latest evidence from the literature and clinical trials regarding treatment options and evaluation of response
  • Features a multidisciplinary approach, with contributions from a range of specialists
This book presents up-to-date information on one of the hottest topics in prostate cancer, namely bone metastases. The most recent developments with respect to biology, pathology, diagnosis, and treatment are described, providing readers with an excellent understanding of the mechanisms of metastasis formation, the characteristics of metastases, their aggressiveness, and prognostic factors for treatment response.

The coverage includes discussion of all of the best available options (laboratory, radiology, and nuclear medicine) for achieving early diagnosis and both established and novel therapeutic approaches. Detailed information is provided on hormonal manipulations, bone-targeted agents, vaccines, taxanes, and other treatments that are enriching the therapeutic armamentarium.

The editors can be considered leaders in the field, with great experience in diagnostic and clinical oncology and research, and the authors are experts in diverse specialties. This ensures a multidisciplinary approach, mirroring the current situation in which treatment in patients with bone metastases is undertaken by a team of specialists and health professionals in a variety of fields.

Table of Contents
  • Biology and pathophysiology of bone metastases
  • Markers of Bone Turnover in Bone Metastasis from Prostate Cancer
  • Bone homing and metastasis
  • Markers of Prostate Cancer: The Role of Circulating Tumor Markers in the Management of Bone Metastases
  • Circulating Tumor Cells (CTCs) and Metastatic Prostate Cancer (mPCa)
  • Nuclear Medicine Modalities to Image Bone Metastases with Bone-Targeting Agents: Conventional Scintigraphy and Positron-Emission Tomography
  • Detection of Bone Metastases and Evaluation of Therapy Response in Prostate Cancer Patients by Radiolabelled Choline PET/CT
  • Imaging of Glycolysis with 18F-FDG PET
  • Bone Metastases from Prostate Cancer: Hormonal Therapy
  • Chemotherapy
  • Combinations of hormonal therapy and chemotherapy
  • Surgery: Treatment of Oligometastatic Disease
  • Bone Metastases from Prostate Cancer: Radiotherapy
  • Bone-targeted agents
  • Bone seeking radionuclide for therapy
  • New frontiers in treatments
  • Approaches for the assessment of response to therapies
  • Bone Metastases from Prostate Cancer: From Symptom Control to Pain Palliation
  • Economic impact of prostate cancer bone metastases
  • Multidisciplinary approach of Prostate Cancer Patients

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