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Manual of Cardiovascular Proteomics


AGNETTI / LINDSEY / FOSTER  

Manual of Cardiovascular Proteomics

430 Seiten, 1. Auflage, 2016
100 Tabellen 65 Abbildungen

  • Contains current information on the practical clinical potential of cardiac proteomics
  • Designed to be read by a broad modern aware audience
  • Contains numerous helpful and revealing images to help the reader visualize the topic​
This book fulfils the need to keep up with the high number of innovations in proteomics, and at the same time to warn the readers about the danger of manufacturers and scientists claims around new technologies.

Mass spectrometry stands as the core technology in proteomics. The emerging field of targeted proteomics and its potential applications in the cardiovascular arena are also reviewed and discussed. A concluding section highilghts the promise of proteomics in the light of these recent developments.​

As this technique and its applications have undergone remarkable advances in the past years, recent updates on proteomic applications are covered. Another key concept revealed by proteomic technologies is that the extent of protein post-translational modifications (PTMs) as well as their impact on the phenotype has been underestimated by pre-proteomics science. As such, part of the manual focuses on the emerging role of PTMs in basic cardiovascular sciences and in the clinics.

In fact, there is an emerging consensus that the detailed annotation of protein PTMs could lead to a more in-depth representation of biological systems, translating into more specific targets for therapy as well as biomarkers. Moreover, a recent trend is so-called “targeted proteomics”. The approach was awarded the title of “Method of the Year” by Nature in 2013 (see the editorial by Vivien Marx in 1st issue of Nature in Jan 2013). According to a few proteomic scientists the emphasis should not be placed on generating long lists of proteins but lists of proteins with a true biological meaning.

Table of Contents
  • A Historical Perspective on Cardiovascular Proteomics
  • Basic Concepts in Mass Spectrometry and Protein Quantitation
  • How to Design a Cardiovascular Proteomics Experiment
  • Organelle, Protein and Peptide Fractionation in Cardiovascular Proteomics
  • Vascular Proteomics
  • Stem Cell Proteomics
  • Bottom-Up Proteomics
  • Top-Down Proteomics
  • Targeted Proteomics (MRM) in Cardiovascular Research
  • Label-Free Quantification by Data Independent Acquisition Mass Spectrometry to Map Cardiovascular Proteomes
  • Labeling and Label-Free Shotgun Proteomics Quantification in the Research of Cardiovascular Diseases
  • Analysis of Proteomic Data
  • Post-translational Modifications in the Cardiovascular Proteome
  • Proteomic Network Systems Analysis
  • Sensing and Remembering Cellular States Through Chromatin
  • Synergizing Proteomic and Metabolomic Data to Study Cardiovascular Systems
  • Clinical Cardiovascular Proteomics
  • Concluding Remarks: Proteomics AD 2025

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