- Presents the latest advances in research into Dupuytren disease and its clinical management
- Spans all relevant specialties
- Reviews comparative studies of treatment approaches
- Debates ongoing controversies
In this book, leading international experts showcase the latest advances in research into Dupuytren disease and its clinical management.
The coverage spans all relevant specialties, including cell biology, biomechanics, genomics, surgery, pharmacotherapy, and radiotherapy. The opening sections address epidemiology, cellular and extracellular events, and genetics. Treatment by means of collagenase injection, percutaneous needle fasciotomy, and other surgical and minimally invasive approaches is then extensively discussed.
Comparative studies of different approaches are reviewed, and aspects of patient assessment, examined. The prevention and treatment of disease recurrences are also addressed. Further sections consider related conditions, other treatment options, and future pathways for research.
This book should be read by all who treat or conduct research into Dupuytren disease. It is based on presentations delivered at the 2015 International Conference on Dupuytren Disease, held in Groningen, the Netherlands, which was designed to promote a coordinated global response to the disease involving patients, scientists, and clinicians.
Table of Contents- The Epidemiology of Surgical Intervention for Dupuytren Contracture in England
- Favorite Options of German Hand Surgeons in the Treatment of Dupuytren Disease
- Trends in Dupuytren Treatment in the United States
- International Patient Survey (Part 1: Dupuytren Disease)
- The Extracellular Matrix in Dupuytren Disease
- Biomarkers of Postsurgical Outcome in Dupuytren Disease
- Tumour Necrosis Factor as a Therapeutic Target in Dupuytren Disease
- Contraction Versus Contracture: Considerations on the Pathogenesis of Dupuytren Disease
- Controversy: The Contracture in Dupuytren Disease Is an Active Process
- Controversy: The Contracture in Dupuytren Disease Is a Passive Process
- Human Genetic Studies of Dupuytren Disease: A Primer
- Network Analysis and Fine-Mapping GWAS Loci to Identify Genes and Functional Variants Involved in the Development of Dupuytren Disease
- Collagenase Injection: Journey from Bench to Current Advanced Clinical Use
- Efficacy of Using Local Anesthesia Before Collagenase Injection in Reducing Overall Pain Experience in Patients Treated for Dupuytren Contracture: A Quasi-Randomized Study
- Effect of Delayed Finger Extension on the Efficacy and Safety of Collagenase Clostridium Histolyticum Treatment for Dupuytren Contracture
- The Use of Dynamic Dorsal Splint for Dupuytren Rehabilitation After Collagenase Injection
- Prospective Multicenter, Multinational Study to Evaluate the Safety and Efficacy of Concurrent Collagenase Clostridium Histolyticum Injections to Treat Two Dupuytren Contractures in the Same Hand
- Collagenase: What We May Never Know (A Discussion)
- Controversy: Comparison of the Literature on PNF and CCH as Minimally Invasive Treatment Options for Dupuytren Disease
- Tips and Pearls for PNF and Collagenase: A Ten-Year Personal Experience
- Clinical Results of Percutaneous Needle Fasciotomy for Dupuytren Contracture: Are There Significant Correlations Between Preoperative Dupuytren Diathesis Score and Contracture Recurrence?
- Effectiveness of Percutaneous Needle Fasciotomy for Second or Higher Recurrence in Dupuytren Contracture
- Controversy: How to Treat Severe PIP Contractures? - Collagenase Treatment
- Controversy: How to Treat Severe PIP Contractures? - Surgical Correction
- Correlation of Function with Deformity in Dupuytren Disease: The Condition-Specific Southampton Scoring Scheme Outperforms the Generic QuickDASH
- Tonometry as an Outcome Measure for the Treatment of Early Dupuytren Disease
- The Intra- and Interobserver Agreement on Diagnosis of Dupuytren Disease, Measurements of Severity of Contracture, and Disease Extent
- Variation in Range of Movement Reporting in Dupuytren Disease
- Use of Digital Photography and Mobile Device Application to Assess Finger Deformity in Dupuytren Diseases
- Application for Determining the Degree and Diagnose Code of Dupuytren Contracture by Digital Photography
- Treatment of Dupuytren Disease: Where Are We Now?
- Steroid Injection and Needle Aponeurotomy for Dupuytren Disease
- Minimally Invasive Treatment of Dupuytren Contracture: Collagenase Versus PNF
- Comparative Effectiveness of Collagenase Injection for Dupuytren Contracture
- Short-Term Cost-Utility Analysis of Collagenase Versus Fasciectomy for Dupuytren Contracture
- An Easy Way for Clinical Validation of the Pharmacoeconomic Model in Dupuytren Disease
- Preliminary Soft-Tissue Distraction with the Digit Widges
- Is Recurrence After Treatment Predictable? Risk Factors in Dupuytren Disease
- Is Recurrence of Dupuytren Disease Avoided in Full-Thickness Grafting?
- The Use of Acellular Dermal Matrix in Dupuytren Disease
- Indications of the Continuous Extension Technique (TEC) for Severe Dupuytren Disease and Recurrences
- Experience in Treating Patients with Stage IV of Dupuytren Contracture (PNF vs. Fasciectomy)
- Controversy: Splinting for Dupuytren Contracture
- Introduction to Radiation Biology When Treating Hyperproliferative Benign Diseases
- Review of Radiation Therapy for Palmar and Plantar Fibromatosis (Dupuytren and Ledderhose Disease)
- Splinting as a Therapeutic Option in Dupuytren Contractures
- Treatment Options for Patients with Adhesive Capsulitis (Frozen Shoulder)
- International Patient Survey (Part 2: Ledderhose Disease)
- Peyronie Disease
- The Next Stage of Clinical Dupuytren Research: Biomarkers and Chronic Disease Research Tools
- The Future of Basic Dupuytren Disease Research
- How Should We Fund Basic Research of Dupuytren Disease?
- Clinical Research: International Collaboration to Execute High-Powered Clinical Trials
- Patient-Rated Outcome Measures and Dupuytren Contracture
- IDDB: An International Research Database of the Dupuytren Foundation
- International Clinical Research – The Australian Perspective: A Personal View
- Open Questions and Potential Answers
