Translational Research in Coronary Artery Disease: Pathophysiology and Treatment covers the entire spectrum of basic science, genetics, drug treatment, and interventions for coronary artery disease.
With an emphasis on vascular biology, this reference on vascular biology, this reference fully explains the fundamental aspects of coronary artery disease pathophysiology.
Included are important topics, including endothelial function, endothelial injury, and endothelial repair in various disease states, vascular smooth muscle function and its interaction with the endothelium, and the interrelationship between inflammatory biology and vascular function.
By providing this synthesis of current research literature, this reference allows the cardiovascular scientist and practioner to access everything they need from one source.
Features:
- Provides a concise summary of recent developments in coronary and vascular research, including previously unpublished data
- Summarizes in-depth discussions of the pathobiology and novel treatment strategies for coronary artery disease
- Provides access to an accompanying website that contains photos and videos of noninvasive diagnostic modalities for evaluation of coronary artery disease
Table of Contents:List of Contributors
Preface
Biographies
Chapter 1. Endothelial Biology: The Role of Circulating Endothelial Cells and Endothelial Progenitor Cells
- Abstract
- What Are Endothelial Progenitor Cells?
- Paracrine Effects of BM-Derived Cells
- Mechanisms, Known and Unknown
- Circulating Endothelial Cells and Microparticles: The Other Side of the Coin?
- Clinical Data and Potential Applications
- Summary and Conclusions
- References
Chapter 2. The Role of Vascular Smooth Muscle Phenotype in Coronary Artery Disease
- Abstract
- Introduction
- Atherosclerosis
- Restenosis
- Arteriogenesis
- Conclusions
- References
Chapter 3. Immuno-Inflammatory Basis of Atherosclerotic Coronary Artery Disease
- Abstract
- Inflammation and CAD—Molecular Mechanisms
- Clinical Associations of Inflammation and CAD
- Imaging the Inflammation in CAD
- Immunity and CAD
- Inflammatory Biomarkers and CAD
- Anti-inflammatory Therapies in CAD
- Immune Therapies in CAD
- Conclusions
- References
Chapter 4. Adiponectin: A Mediator of Obesity, Insulin Resistance, Diabetes, and the Metabolic Syndrome
- Abstract
- Role of Oxidative Stress and Inflammation in Obesity
- Cytoprotective Heme Oxygenase/Adiponectin Axis
- Adiponectin
- Structure and Secretion of Adiponectin
- Adiponectin Receptors: Structure and Function
- Adiponectin in Obesity
- Adiponectin as an Insulin-Sensitizing Hormone
- Adiponectin and Atherosclerosis
- Adiponectin and Hypertension
- Adiponectin and Dyslipidemia
- Adiponectin and the Metabolic Syndrome
- Current and Future Therapeutic Targets
- References
Chapter 5. Use of Stem Cells in Ischemic Heart Disease
- Summary/Abstract
- Introduction
- Mechanism of Action
- Stem Cell Delivery
- Types of Stem Cells
- Conclusions
- References
Chapter 6. Vasculogenesis and Angiogenesis
- Abstract
- Vasculogenesis
- Angiogenesis
- Therapeutic Vasculogenesis/Angiogenesis for Ischemic Heart Disease
- Summary
- References
Chapter 7. Lipids in Coronary Heart Disease: From Epidemiology to Therapeutics
- Abstract
- Introduction
- Nonpharmacologic Management of Lipids
- LDL-C and LDL-Targeted Therapeutics
- HDL-C and HDL-Targeted Therapeutics
- Triglycerides
- Conclusion
- References
Chapter 8. Genetics of Coronary Disease
- Abstract
- The GWAS Era
- Importance of Defining the Phenotype
- Significance and Replication
- Biological and Functional Relevance
- The 9p21.3 Risk Locus
- SORT1/CELSR2/PSRC1
- PCSK9
- SH2B3
- Additional GWAS Variants Associated with CAD
- Assessing Genetic Risk
- Future Directions
- Summary
- References
Chapter 9. The Role of Nitric Oxide and the Regulation of Cardiac Metabolism
- Abstract
- Functional Anatomy of the Heart
- Role of Nitric Oxide and Reactive Dilatation in Coronary Artery Vasomotion
- Organic Nitrates, Prostanoids, and Vasoconstrictors
- NO as a Mediator of Pharmaceutical Agents
- Conclusion
- References
Chapter 10. Revascularization for Silent Myocardial Ischemia
- Abstract
- Pathophysiology of Silent Myocardial Ischemia: A Historical Perspective
- Magnitude of the Problem
- Prognostic Significance of Silent Myocardial Ischemia
- Revascularization for Silent Myocardial Ischemia
- Role of Myocardial Ischemia in Decision Making
- Conclusion
- References
Chapter 11. Noninvasive Diagnostic Modalities for the Evaluation of Coronary Artery Disease
- Abstract
- Introduction
- Conclusion
- References
Chapter 12. Current Approaches to Treatment of Ventricular Arrhythmias in Patients with Coronary Artery Disease
- Abstract
- Introduction
- VAS in the Setting of Acute Ischemia and Infarction
- VAS in the Setting of ICM
- Medical Therapy
- Implantable Cardiac Defibrillator
- Conclusions
- References
Chapter 13. Magnetic Resonance Imaging for Clinical Use and Research Investigation in Coronary Artery Disease
- Abstract
- Introduction
- Technique
- Coronary MRA Technique
- Field Strength
- Acquisition Techniques Available for Coronary MRA
- Coronary MRA Compared to CCTA
- Current Applications
- CCTA Compared to Coronary MRA
- Role of Coronary MRA in Specific Patient Populations
- Conclusions
- References
hapter 14. Invasive Diagnostic Assessment of Coronary Artery Disease
- Summary/Abstract
- Fractional Flow Reserve
- Intravascular Ultrasound
- Optical Coherence Tomography
- IVUS and FFR in Assessment of Left Main Disease
- Near Infrared Spectroscopy
- Conclusions
- References
Chapter 15. Drug Treatment of Stable Coronary Artery Disease
- Summary/Abstract
- Risk Factor Reduction
- Aspirin
- Clopidogrel
- Vorapaxar
- Anticoagulants
- Beta-Adrenergic Blockers
- Nitrates
- Other Antianginal Drugs
- Angiotensin-Converting-Enzyme Inhibitors
- Aldosterone Antagonists
- Calcium Channel Blockers
- Antiarrhythmic Therapy
- Hormone Replacement Therapy
- Influenza Vaccination
- Depression
- Cardiac Rehabilitation
- Coronary Revascularization
- References
Chapter 16. Percutaneous Coronary Intervention
- Abstract
- History
- Indications
- Vascular Access
- Intracoronary Devices
- Antiplatelet Agents
- Anticoagulants
- Complications of PCI
- Controversies and Future Directions
- Conclusions
- References
Chapter 17. Current Topics in Bypass Surgery
- Abstract
- Introduction
- CABG versus PCI
- Multiarterial Grafting
- Off-Pump versus On-Pump CABG
- Postoperative Stroke
- Minimally Invasive CABG and HCR
- Disclosures
- References
Chapter 18. Peripheral Veno-arterial Extracorporeal Membrane Oxygenation for Treatment of Ischemic Shock
- Abstract
- Introduction
- Evolution to Contemporary ECMO
- Indications
- Technical Considerations
- Management Considerations
- Clinical Outcomes
- Ethics
- Economics
- Conclusions
- References
Chapter 19. Biostatistics Used for Clinical Investigation of Coronary Artery Disease
- Summary/Abstract
- Introduction
- Observational Study
- Experimental Study
- Discussion
- References
Index
