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- Provides a comprehensive view of both consolidated and innovative concepts in diagnosis and treatment
- Emphasizes the necessity of combining local and systemic treatments
- Covers topics such as epidemiology and etiology, diagnosis modalities, global management of individual cancers, quality assurance programs, patient rehabilitation, salvage treatments, health economics, and psycho-oncology
- Discusses new surgery and radiotherapy techniques, disease awareness, patient quality of life, and comprehensive management
- Provides a detailed update of innovative concepts in chemo-and bio-radiation, viral infection impact on tumor growth and response to treatment, and impact of tumor and host-related factors on treatment outcome
This second edition provides a comprehensive view of consolidated and innovative concepts, in terms of both diagnosis and treatment. Written by leading international physicians and investigators, this book emphasizes the necessity of combining local and systemic treatments to achieve the objective of yielding higher cure rates and lower toxicities. Heavily updated from the previous edition, it highlights new surgery and radiotherapy techniques, disease awareness, patient quality of life, and comprehensive management. Head-and-neck cancers are a complex clinical entity and their response to treatment is also known to vary markedly in function of host-related factors. Notwithstanding the impressive progresses observed in the field of imaging, head and neck cancers are often diagnosed at a late stage and the presence of locally advanced disease in a significant number of patients implies the use of aggressive treatments in order to both ensure local disease control and reduce distant metastasis risks. In comparison with the first edition, Head and Neck Cancer, Second Edition provides a detailed update of innovative concepts in chemo- and bio-radiation, viral infection impact on tumor growth and response to treatment, and impact of tumor- and host-related factors on treatment outcome. Table of Contents- Ch. 1: Epidemiology and Aetiology of Head and Neck Cancers
Newell W. Johnson Hemantha K. Amarasinghe - Ch. 2: Head and Neck Cancer Prevention
Fausto Chiesa Angelo Ostuni Roberto Grigolato Luca Calabrese Mohssen Ansarin - Ch. 3: Cellular and Molecular Pathology of Head and Neck Tumors
Adel K. El-Naggar - Ch. 4: Oncogenomics/Proteomics of Head and Neck Cancers
Jason I. Kass Howard S. Moskowitz Jennifer R. Grandis - Ch. 5: Genetics and Epigenetics of Head and Neck Cancer
Jagtar Dhanda Richard J. Shaw - Ch. 6: Immunology of Head and Neck Cancer
Benjamin A. Kansy Steve C. Lee Robert L. Ferris - Ch. 7: Biomarkers in Head and Neck Cancer
Hyunseok Kang Christine H. Chung Arlene A. Forastiere - Ch. 8: HPV and EBV in Head and Neck Cancer Jeffrey Brumbaugh Robert L. Ferris Shen Hu
- Ch. 9: Head and Neck Cancer Staging and Prognosis: Perspectives of the UICC and the AJCC
Brian O'Sullivan Jatin P. Shah William M. Lydiatt - Ch. 10: Preclinical Models of Head and Neck Squamous Cell Carcinoma C.L. Zuur A.J.C. Dohmen Michiel W. van den Brekel Xiao-Jing Wang Stephen Malkoski
- Ch. 11: Translational Research in Head and Neck Oncology
David S. Yoo David M. Brizel - Ch. 12: Hypoxia in Head and Neck Cancers: Clinical Relevance and Treatment
Yungan Tao Jean Bourhis - Ch. 13: Imaging of Head and Neck Cancers
Taha S. Meraj Suyash Mohan Gaurang V. Shah - Ch. 14: Ultrasound Investigations in Head & Neck Cancer Patients
Yolanda Y.P. Lee Ka Tak Wong Kunwar Suryaveer Singh Bhatia Anil Tejbhan Ahuja - Ch. 15: Sentinel Node Biopsy
Oliver J. Smith Lee W.T. Alkureishi Gary L. Ross - Ch. 16: Intensity-Modulated Radiation Therapy for Head and Neck Cancer
Marsha Reyngold Edward J. Shin Nancy Lee - Ch. 17: Stereotactic Radiotherapy in Head and Neck Cancer Patients
Thomas Leroy Eric Lartigau - Ch. 18: Proton Beam Therapy for Head and Neck Cancer
Danielle N. Margalit Judy A. Adams Hanne M. Kooy Annie W. Chan - Ch. 19: Principles of Systemic Chemotherapy for Squamous Cell Head and Neck Cancer
Cristina P. Rodriguez David J. Adelstein - Ch. 20: Molecular Targeted Therapies in Head and Neck Cancer
Zachary S. Morris Anne M. Traynor Paul M. Harari - Ch. 21: Laser Endoscopic Treatment
Pierre Moreau Pierre Demez - Ch. 22: Transoral robotic surgery in head and neck cancer
Sylvain Morinière - Ch. 23: Multidisciplinary Management of Skull Base and Superstructure Tumors
Giulio Cantù Carlo L. Solero Stefano Riccio Sarah Colombo Madia Pompilio - Ch. 24: Multidisciplinary management of oral cavity and maxillary sinus cancers
Alexander D. Rapidis - Ch. 25: Oral Oncology
Ruth Aponte Wesson Theresa M. Hofstede Richard C. Cardoso Pattii Montgomery Alexander M. Won Jack W. Martin Mark S. Chambers - Ch. 26: Management of Nasopharyngeal Carcinoma
Wai Tong Ng Roger K.C. Ngan Siu Hong Chan Henry Sze Jimmy Y.W. Chan Anne W.M. Lee - Ch. 27: Multidisciplinary management of oropharynx carcinomas
Beth M. Beadle David I. Rosenthal - Ch. 28: Multidisciplinary Management of Hypopharyngeal Carcinoma Marc Hamoir
Jean-Pascal Machiels Sandra Schmitz Vincent Gregoire - Ch. 29: Cancers of the Larynx: Tis, T1, T2 Evaluation and Management
Carol M. Lewis Steven B. Chinn Chris Holsinger Randal S. Weber - Ch. 30: Diagnosis and Multidisciplinary Treatment of Laryngeal Cancers
Nabil F. Saba J. Trad Wadsworth Jonathan J. Beitler Fadlo R. Khuri - Ch. 31: Programs of Organ and Function Preservation
Jean Louis Lefebvre - Ch. 32: Principles and New Approaches in Surgical Reconstruction
Andreas Dietz Milos Fischer Christina Magill Bruce H. Haughey - Ch. 33: Multidisciplinary treatment of the neck
Remco de Bree Johannes A. Langendijk C.R. Leemans - Ch. 34: Postoperative Management of High-Risk Resectable Head and Neck Cancer
Assuntina G. Sacco Ezra E. Cohen - Ch. 35: Multidisciplinary Approach of Unresectable Head and Neck Cancer
Ricardo Hitt Ana Lopez-Martin Juan J. Cruz Robert I. Haddad - Ch. 36: Management of Salivary Gland Cancer
Laura D. LocatiMarco GuzzoEster OrlandiLisa Licitra - Ch. 37: Primary Mucosal Melanomas of the Head and Neck
Juliette Thariat Anne-Catherine Baglin Pierre Yves Marcy Caroline Even Antoine Moya-Plana Yusuke Demizu Adam S. Garden Marco Krengli Michael A. Postow - Ch. 38: Head & Neck Cutaneous Melanoma
Mina N. Le Michael A. Postow Snehal G. Patel - Ch. 39: Cervical Lymph Node Metastases Of Squamous Cell Carcinoma From An Unknown Primary Site
Nicholas Pavlidis Georgios Plataniotis - Ch. 40: The Management of Thyroid and Parathyroid Cancer
Nasheed M. Hossain Colleen Veloski Ranee Mehra - Ch. 41: Head and Neck Paragangliomas
Julian Künzel Michael Hainz Heidi Rossmann Christoph Matthias - Ch. 42: Systemic Treatment of Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck
Petr Szturz Jan B. Vermorken - Ch. 43: Phase I study methodology in head and neck oncology
Aaron Hansen Christophe Le Tourneau - Ch. 44: Treatment of the Elderly Head and Neck Cancer Patient
Jean-Claude Horiot Matti Aapro - Ch. 45: Normal Tissue Complications and Protection in Head and Neck Cancer Patients
Andy Trotti Nikhil Rao Avraham Eisbruch David I. Rosenthal - Ch. 46: Advances in Management of Complications for Head and Neck Cancer Therapy
Barbara Murphy Jie Deng Mark J. Stavas Heidi Ganzer Joel B. Epstein - Ch. 47: Rehabilitation of Heavily Treated Head and Neck Cancer Patients
Katherine A. Hutcheson - Ch. 48: Salvage Therapy in Head and Neck Cancer Patients
John Heaphy Rod Rezaee Pierre Lavertu - Ch. 49: Quality of Life in Head and Neck Cancer Patients
Jolie Ringash - Ch. 50: Psycho-oncologic aspects of head and neck cancer patients
Michel Reich - Ch. 51: Advances in Nanomedicine for Head and Neck Cancer
Sajanlal R. Panikkanvalappil Mostafa A. El-Sayed Ivan H. El-Sayed - Ch. 52: Head and Neck Quality Assurance 2014
Thomas J. Fitz Gerald Maryann Bishop-Jodoin David S. Followill James M. Galvin Michael V. Knopp Jeff M. Michalski Mark Rosen Jonathan M. Glanzman Paul Rava Allison Sacher David J. Goff Alec Vaezi Kenneth Ulin
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