The Treatment of Epilepsy, fourth edition, is a comprehensive reference and clinical guide to the pharmacological, medical and surgical options available in the treatment of epilepsy. - The text is compiled by a group of internationally renowned editors and contributors and is now in full color and extensively illustrated
- The first two sections cover the background to, and principles of, treatment in different clinical situations
- Section three comprises a series of systematic reviews of contemporary drug therapy, devoting one chapter to each anti-epileptic drug and covering all clinically-relevant aspects
- Section four focuses on the surgical options, devoting individual chapters to each of the modalities of presurgical assessment and to each surgical operation or approach
- This 4th edition is extensively revised incorporating the many recent developments in therapy, and comprises 81 chapters from world experts from 18 countries
ContentsList of Contributors Preface to the Fourth Edition Historical Introduction: The Drug Treatment of Epilepsy From 1857 to 2015 Simon Shorvon Section 1 Introduction (Lead editor: Simon Shorvon) - 1 Classification, aetiology, and investigation of epilepsy
Simon Shorvon - 2 Differential Diagnosis of Epilepsy
Mark Cook - 3 Epileptogenesis and its prevention
Giuliano Avanzini, Silvana Franceschetti - 4 Antiepileptic Drug Discovery H. Steve White, Melissa Barker-Haliski
- 5 Antiepileptic drug development Dieter Schmidt
- 6 Mechanisms of Antiepileptic Drug Action
Matthew C. Walker, Rainer Surges - 7 Mechanisms of Tolerance and Drug Resistance
Wolfgang Loscher, Dieter Schmidt - 8 Epilepsy Biomarkers
Asla Pitkanen, Jerome Engel Jr
Section 2 - Principles of Medical Management (Lead Ed: Simon Shorvon) - 9 General Principles of Medical Management
Emilio Perucca - 10 Pharmacokinetic optimisation of therapy
Svein Johannessen, Cecilie Johannessen-Landmark, Emilio Perucca - 11 Clinical approaches to management of adult epilepsy
Simon Shorvon - 12 Management of Epilepsy in Remission
Patrick Kwan, Howan Leung, Xiaoting Hao - 13 Management of Epilepsy in the first year of life
Elissa G. Yozawitz, Solomon L. Moshe - 14 Management of Childhood Epilepsy Syndromes and epilepsy in specific diseases of childhood
Colin D. Ferrie - 15 Management of epilepsy in people with learning disabilities
Eylert Brodtkorb - 16 Management of Epilepsy in the Elderly
Hiba Arif, Lawrence J Hirsch - 17 Emergency Treatment of Seizures and Status Epilepticus
Matthew C. Walker, Simon Shorvon - 18 Management of medical co-morbidies associated with epilepsy
Gagandeep Singh - 19 Management of psychiatric co-morbidities associated with epilepsy
Brent Elliott, Simon Shorvon - 20 Prevention and Management of Side-effects of Antiepileptic Drugs
Gaetano Zaccara, Piero Perucca - 21 Ketogenic and related diets
Eric H. Kossoff, Courtney A. Haney - 22 Complementary and Alternative Treatments for Epilepsy
Sallie A. Baxendale - 23 Reproductive Aspects of Epilepsy Treatment Torbjorn Tomson
- 24 Genetic Counselling in Epilepsy
Federico Zara - 25 Drug Interactions
Edoardo Spina, Domenico Italiano - 26 Medical Treatment of Epilepsy in Situations with Limited Resources
Patrick Adjei
Section 3 - Antiepileptic Drugs (Lead editor: Emilio Perucca) - 27 Introduction to the Choice of Antiepileptic Drugs Emilio Perucca
- 28 Acetazolamide
Miri Y. Neufeld - 29 Adrenocorticotropic Hormone and Corticosteroids Federico Vigevano, Maria Roberta Cilio
- 30 Benzodiazepines used in epilepsy
Eugen Trinka, Francesco Brigo - 31 Brivaracetam
Joseph D'Souza, Emilio Perucca - 32 Carbamazepine
Torbjorn Tomson - 33 Eslicarbazepine Acetate
Meir Bialer, Christian Elger - 34 Ethosuximide
Tracy A. Glauser, Emilio Perucca - 35 Felbamate
Ilo E. Leppik, James R. White - 36 Gabapentin Ernest
R. Somerville, Andrew W. Michell, Arjune Sen - 37 Lacosamide
Rajesh Sachdeo, Roopal Karia - 38 Lamotrigine
Fumisuke Matsuo, Awais Riaz - 39 Levetiracetam
Jacqueline A. French, Derek Chong - 40 Oxcarbazepine
Edward Faught Jnr., Hyunmi Kim - 41 Perampanel
Martin J. Brodie - 42 Phenobarbital, Primidone and Other Barbiturates Roberto Michelucci, Elena Pasini
- 43 Phenytoin
Mervyn J. Eadie - 44 Piracetam
Simon Shorvon - 45 Pregabalin
Philippe Ryvlin - 46 Retigabine
Michel Baulac - 47 Rufinamide
Victor Biton - 48 Stiripentol
Tapani Keranen - 49 Tiagabine
Reetta Kalviainen - 50 Topiramate
J. Helen Cross, Catherine J. Riney - 51 Valproate
Anthony G. Marson, Graeme J. Sills - 52 Vigabatrin
Gunter Kramer, Gabriele Ch. Wohlrab - 53 Zonisamide Michel Baulac
- 54 Other Drugs Rarely Used
Martin Holtkamp - 55 Drugs in Clinical Development
H. Steve White, Norman Delanty
Section 4 Presurgical Assessment and Epilepsy Surgery (Lead editor: Jerome Engel Jr) - 56 Overview of Surgical Treatment for Epilepsy
Jerome Engel Jr - 57 Scalp EEG in the Epilepsy Surgery Evaluation
John M. Stern, Christine B. Baca - 58 Invasive EEG in Presurgical Evaluation of Epilepsy
Dennis Spencer, Adithya Sivaraju - 59 MEG in epilepsy surgery evaluation Hermann Stefan, Paul Boon
- 60 MRI in the Presurgical Evaluation Christian E. Elger, Bernd Weber
- 61 PET and SPECT in Presurgical Evaluation of Epilepsy
Karolien Goffin, Wim Van Paesschen - 62 Special Neurophysiological Techniques
Francois Mauguiere, Julien Jung - 63 Neuropsychological Testing in Presurgical Evaluation
Marilyn Jones-Gotman, Gail L. Risse - 64 Presurgical Psychiatric Evaluation
Andres M. Kanner - 65 Mesial Temporal Lobe Surgery and Other Lobar Resections
Itzhak Fried, James W. Leiphart - 66 Resective Surgery of Neoplasms Gregory D. Cascino, Nicholas M. Wetjen
- 67 Resective Surgery of Vascular and Infective Lesions for Epilepsy
Christopher E Uff, Neil D Kitchen - 68 Surgery of Developmental Anomalies Causing Epilepsy
Ahyuda Oh, Joshua J. Chern, Youssef G. Comair - 69 Hemispheric operations for Epilepsy
Georg Dorfmuller, Christine Bulteau, Olivier Delalande - 70 Corpus Callosotomy
David W. Roberts - 71 Hypothalamic Hamartoma
John F. Kerrigan - 72 Multiple subpial transection
Adriana Bermeo-Ovalle,Michael C. Smith - 73 Awake Surgery for Epilepsy Webster H. Pilcher
- 74 Epilepsy Surgery in Children
Jason S. Hauptman, Gary W. Mathern - 75 Complications of Epilepsy Surgery Charles E. Polkey
- 76 Anaesthesia for Epilepsy Surgery
Barbara M. Van de Wiele - 77 Vagal Nerve Stimulation
Steven C. Schachter - 78 Brain Stimulation for Epilepsy
Gregory K. Bergey, Robert S. Fisher - 79 Non-Resective Approaches for Medically Intractable Epilepsy
Thomas J. Gianaris, Andrea G. Scherer,Nicholas M. Barbaro - 80 Future focal treatments for epilepsy
Hannah Cock, Laura Mantoan Ritter - 81 Epilepsy Surgery in Countries with Limited Resources
Andre Palmini, Kurupath Radhakrishnan
Index
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