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Neuroinflammation has long been studied for its connection to the development and progression of Multiple Sclerosis. In recent years, the field has expanded to look at the role of inflammatory processes in a wide range of neurological conditions and cognitive disorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers have also started to note the beneficial impacts of neuroinflammation in certain diseases.
Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides a comprehensive view of both the detriments and benefits of neuroinflammation in human health.
Neuroinflammation: New Insights into Beneficial and Detrimental Functions opens with two chapters that look at some fundamental aspects of neuroinflammation in humans and rodents. The remainder of the book is divided into two sections which examine both the detrimental and beneficial aspects of inflammation on the brain, spinal cord and peripheral nerves, on various disease states, and in normal aging. These sections provide a broad picture of the role neuroinflammation plays in the physiology and pathology of various neurological disorders.
Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficial and Detrimental Functions will be an essential volume for neuroimmunologists, neurobiologists, neurologists, and others interested in the field.
Contents
List of Contributors
Preface
PART I Introduction
1 Immune Response in the Human Central Nervous System in Multiple Sclerosis and Stroke - Hans Lassmann
2 In Vivo Imaging of Glial and Immune Cell Responses in Central Nervous System Injury and Disease - Alexandre Paré and Steve Lacroix
PART II Detrimental Aspects of Inflammation
3 Roles of CD4 and CD8 T Lymphocytes in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis - Nathalie Arbour and Alexandre Prat
4 Microglia and Macrophage Responses and Their Role after Spinal Cord Injury 53 - Antje Kroner, Andrew D. Greenhalgh, and Samuel David
5 The Complexity of the Innate Immune System Activation in Stroke Pathogenesis - María Isabel Cuartero, Ignacio Lizasoain, María Ángeles Moro, and Ivan Ballesteros
6 Neuroinflammation in Aging -Ashley M. Fenn, Diana M. Norden, and Jonathan P. Godbout
7 Peripheral and Central Immune Mechanisms in Neuropathic Pain - Ji Zhang
ropathic Pain
8 Inflammation in the Pathogenesis of Inherited Peripheral Neuropathies - Janos Groh, Dennis Klein, Antje Kroner, and Rudolf Martini
9 Obesity- and Neuroinflammation-Associated Mood and Cognitive Disorders -
Nathalie Castanon, Giamal Luheshi, and Sophie Layé
10 Viral Infections of the Central Nervous System: Pathogenic and Protective Effects of Neuroinflammation - John G. Walsh and Christopher Power
PART III Beneficial Aspects of Inflammation
11 The Interplay between the Peripheral and Local Immune Response in Recovery from Acute Central Nervous System Injuries - Catarina Raposo and Michal Schwartz
12 Inflammation and Optic Nerve Regeneration - Lukas Andereggen, Ephraim F. Trakhtenberg, Yin Yuqin, and Larry I. Benowitz
13 Effects of Macrophages and Monocytes in Remyelination of the CNS - Muktha Natrajan, Bibiana Bielekova, and Robin J.M. Franklin
14 Microglia Involvement in Rett Syndrome - Noël C. Derecki, James C. Cronk, and Jonathan Kipnis
15 The Role of Regulatory T Cells and Microglia in Amyotrophic Lateral Sclerosis - David R. Beers, Weihua Zhao, Kristopher G. Hooten, and Stanley H. Appel
16 An Adaptive Role for TNFin Synaptic Plasticity and Neuronal Function - Renu Heir and David Stellwagen
17 Resolution of Inflammation in the Lesioned Central Nervous System - Jan M. Schwab, Harald Prüss, and Charles N Serhan
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