- Discusses in detail the pathophysiologic mechanisms of arterial disease
- Explains a range of important novel concepts
- Covers arterial disease in systemic disorders
- Explores the role of macrocirculation/microcirculation interaction in target organ damage
As our knowledge about arterial disease is greatly expanding, the aim of this book is to explore all aspects of arterial pathology, including classification, clinical manifestations, pathogenesis, and therapeutic options. The discussion of pathophysiologic mechanisms of arterial disease is wide ranging, encompassing hemodynamic, metabolic, humoral, inflammatory, genetic and environmental factors.
Particular emphasis is placed on recent concepts, such as: the role of age-associated arterial alterations in the initiation and progression of cardiovascular diseases in older persons, the importance of mineral metabolism-bone vascular interactions, the clinical and prognostic significance of the renal resistive index, retinal circulation, toxemia of pregnancy as an arterial disease, and the role of pulmonary/vascular interaction in pulmonary hypertension and cross-talk of macrocirculation and microcirculation in target organ involvement. Evaluation procedures are carefully explained, and the full range of currently available therapeutic options, including lifestyle modifications and pharmacologic approaches, are described and appraised.
Table of ContentsPART I Introduction:
- Definition/Epidemiology of arterial disease
PART II Normal structure and physiology of the arterial system
PART III Classification of arterial pathology and clinical manifestations:
- Atherosclerosis
- Arteriosclerosis
- Disease of Precapillary resistance vessels
PART IV Pathogenetic mechanisms in arterial disease:
- Hemodynamic and mechanical factors
- Metabolic factors
- Inflammatory markers
- Neurohormonal interactions
- Mineral-bone/ arterial interactions
- Endothelial function and impairment
- Miscellaneous: Pharmacologic/factors/environmental factors
PART V Systemic arterial disorders:
- Arterial aging
- Diabetes mellitus
- Metabolic Syndrome/obesity
- Chronic kidney disease/Renovascular interactions
- Pulmonary Hypertension/Pulmonary vascular interactions
- Systemic vasculitides
- Genetic/ degenerative disorders
- Hypertension
- Toxemia of pregnancy
- Kidney transplants, both donors and recipients
PART VI Evaluation procedures:
- Arterial function
- Renal resistive index
- Retinal microcirculation
PART VII Therapeutic options:
- Lifestyle modifications
- Pharmacologic approaches
