- Presents optical, technological, biomedical and clinical perspectives on and applications from optical coherence tomography (OCT)
- Supports a broad and multidisciplinary audience with explanations for undergraduates and current information for medical professionals and clinical investigators
- Brings readers the latest clinical and engineering developments from the best optical coherence tomography groups worldwide
Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue. Between 30 to 40 Million OCT imaging procedures are performed per year in ophthalmology.
The overall market is estimated at more than 0.5 Billion USD.
A new generation OCT technology was developed, dramatically increasing resolution and speed, achieving in vivo optical biopsy, i.e. the visualization of tissue architectural morphology in situ and in real time. Functional extensions of OCT technology enable non-invasive, depth resolved functional assessment and imaging of tissue.
The book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from the biomedical and clinical perspective. This second edition is widely extended and covers significantly more topics then the first edition of this book. The chapters are written leading international research groups, in a style comprehensible to a broad audience. It will be of interest not only to physicists, scientists and engineers, but also to biomedical and clinical researchers from different medical specialties.
Table of ContentsPreface.- Introduction to Optical Coherence Tomography (OCT) .- Theory of OCT.- Modeling Light-Tissue Interaction in OCT Systems.- Inverse Scattering Techniques in PCI and OCT.- Spectral/Fourier Domain OCT.- Complex and Coherence-Noise Free Fourier Domain OCT.- Optical Frequency Domain Imaging.- Complex Conjugate Removal in SS OCT.- Ultrahigh Resolution OCT.- Ultrahigh Speed OCT.- Optical Design for OCT.- Linear OCT Systems Data Analysis and Signal Postprocessing for OCT.- DSP Technology and Methods for OCT.- OCT Motion Correction.- Segmentation.- Image Processing in Intravascular OCT.- Superluminiscent Diode Light Sources for OCT.- SLEDs and Swept Source Laser Technology for OCT.- Broad Bandwidth Laser and Nonlinear Optical Light Sources for OCT.- Nonlinear Continuum Generation Light Sources.- Wavelength Swept Lasers.- Swept Light Sources.- VCSEL Swept Light Sources.- FDML (incl. Parallelization).- Full Field, Line Field, Partial Field OCT.- FF OCT.- Optical Coherence Microscopy.- OCM with Engineered Wavefront.- Holographic Optical Coherence Imaging.- Interferometric Synthetic Aperture Microscopy (ISAM).- Contrast Enhanced, Functional and Multimodal OCT.- Polarization-Sensitive OCT.- MUW Approach of PS OCT.- Jones Matrix Optical Coherence Tomography.- Using Low Coherent Light for Spectroscopic Information from Tissue.- Motility Contrast Imaging and Tissue Dynamics Spectroscopy.- Elastic Scattering Spectroscopy and OCT.- Nonlinear Interferometric Vibration Imaging (NIVI) with Novel Optical Sources.- Ultrasensitive Phase-Resolved Imaging of Cellular Morphology and Dynamics.- Optophysiology.- Doppler Optical Coherence Tomography.- Doppler OCT.- Optical Microangiography Based on Optical Coherence Tomography.- Doppler Angiography.- Clinical Applications of Doppler OCT and OCT Angiography.- Molecular OCT Contrast Enhancement and Imaging.- Optical Tissue Clearing to Enhance Imaging Performance for OCT.- Second harmonic OCT and combined MPM/OCT.- Combined Endoscopic OCT and Laser Induced Fluorescence.- Integrated Optical Coherence Tomography (OCT) with Fluorescence Laminar Optical Tomography (FLOT).- Photoacoustic / OCT.- OCT and Single or Multiphoton Fluorescence Endoscopy.- OCT and US in Endoscopy.- OCT Applications.- Anterior Eye OCT.- Anterior Segment and Full Eye Biometry.- Retinal OCT Imaging.- OCT Imaging in Glaucoma.- Intraoperative Retinal OCT.- En-face Flying Spot OCT/Ophthalmoscope.- Long Wavelength Retinal/Choroidal OCT.- Retinal AO OCT.- Small Animal Retinal Imaging.- Acousto Optic Modulation Based En-face AO SLO OCT.- OCT in Tissue Engineering.- OCT Applications in Developmental Biology.- 4D OCT in Developmental Biology.- OCT and Coherence Imaging for Brain Science.- OCT for Gastrointestinal Endoscopy.- Endoscopic OCT.- GI OCT.- Intracoronary Optical Coherence Tomography.- Intravascular OCT.- Multimodal Intravascular OCT.- OCT in Dermatology.- Dental OCT.- Anatomic OCT of Upper Airways.- OCT in Pulmonary Medicine.- OCT in Gynecology.- OCT for Cervical Imaging.- OCT in Urology.- OCT in Kidney Transplantation.- Intraoperative OCT in Surgical Oncology.- OCT for Examination of Artwork.- Nondestructive Material Testing using OCT.- OCT Technology Transfer and the OCT Market.
