- Covers all aspects of surgical and medical intervention in metastatic bone disease
- Presents biology, work-up, medical therapy, radiation and interventional oncology, and more
- Features rich and detailed images for diagnostic and referential purposes
Skeletally related events make up approximately 20% of the cancer care economy.
Advances in understanding the pathobiology and better biotargeted therapy and improved surgical technology are occurring continuously. Hundreds of thousands of patients are living longer with ever-increasing tumor burden, but patients can remain siloed in their care as they navigate across subspecialty treatments. This comprehensive text ties it all together around the patient, integrating all aspects of care.
Providing an integrated approach to the diagnosis and management of patients with metastatic bone disease (MBD), this revised and expanded text combines discussion of the pathobiology of the disease with the latest oncological and orthopedic treatment modalities. After opening with an examination of the epidemiology and impact of MBD, the biology of bone metastases are discussed, along with considerations of the tissue of origin, evaluation, biopsy and medical therapy, including metabolic agents and biotargeting.
The heart of the book presents oncological approaches (supportive, radiation and interventional) and principles of orthopedic surgical oncology, with subsequent chapters covering specific anatomy, from the pelvis to the lower extremity and the spine. Chapters on emerging surgical technology and future directions conclude the text. New to this edition are considerations around patient-reported outcomes.
Utilizing the latest clinical evidence and treatment techniques,
Metastatic Bone Disease, Second Edition is standalone resource reflecting a comprehensive, patient-centric resource for all types of providers.
Table of ContentsPart I The Problem 1 Bone Metastases: Epidemiology and Societal Effect Part II Biology of Metastases and Tissue of Origin Considerations 2 Pathobiology of Osteolytic and Osteoblastic Bone Metastases 3 Tissue Engineered Models to Study Bone Mets 4 Biology of Bone Cancer Pain 5 Breast Cancer Bone Metastases 6 Prostate Cancer Bone Metastasis 7 Lung Cancer Bone Metastasis 8 Kidney Cancer Bone Metastasis 9 Thyroid Cancer Bone Metastasis 10 Myeloma Part III Work-Up for Patients with Suspected Metastatic Bone Disease 11 Evaluation of the Patient with Carcinoma of Unknown Origin Metastatic to Bone 12 Biopsy Considerations Part IV Medical Therapy 13 Bisphosphonates, Denosumab, and Anabolic Agents in the Treatment of Metastatic Bone Disease 14 Biotargeting in Metastatic Bone Disease Part V Supportive Oncology 15 Psychosocial Considerations for Patients with Metastatic Bone Disease 16 Pain Management in Metastatic Bone Disease 17 When Is Hospice Appropriate? The Role for Hospice in Palliating Patients with Bone Metastases 18 PROs Part VI Radiation Oncology 19 Current and Emerging Modalities Part VII Interventional Oncology 20 Ablation and Cementation Technologies Part VIII Principles of Orthopedic Surgical Oncology 21 Issues Facing the Established Metastatic Bone Disease Patient, Timing/Indications for Surgery 22 Questions to Ask Your Medical Oncology Colleagues 23 Consideration of the Temporal Relationship Between Surgery and Radiation Therapy 24 Role of Surgery in Oligometastatic Disease Part IX Specific Anatomic Considerations for Surgery 25 Metastatic Bone Disease: Pelvis 26 Metastatic Bone Disease: Femur 27 Metastatic Bone Disease: Femur, Tibia 28 Metastatic Bone Disease: Foot 29 Metastatic Bone Disease: Humerus and Scapula 30 Metastatic Bone Disease: Forearm, Hand 31 Metastatic Bone Disease: Spine Part X Emergent Surgical Technologies 32 Intraoperative Imaging and Navigation Part XI Putting It All Together 33 Integrative Approach with the Patient in Mind: A Glance Forward
