- State-of-the-art contents
- Comprehensive work on CSF testing methods and diagnostic parameters
- With numerous illustrations
The cerebrospinal fluid (CSF) is an invaluable diagnostic tool in clinical neurology, not only in the evaluation of inflammatory, degenerative, and malignant diseases of the nervous system, but also in the diagnosis of all forms of cerebral and subarachnoidal bleedings. The CSF can be easily obtained by lumbar puncture and a set of basic analyses can be investigated with relatively simple laboratory methods. With the combination of a few CSF parameters, a wide range of diagnostic entities can be differentiated. However, the interpretation of test results requires a high level of expertise and cannot be achieved by just reporting single analytic values.
This book covers essential topics of cerebrospinal fluid analysis and its use in the diagnosis of common neurological diseases. The first part addresses preclinical aspects such as CSF history as well as the anatomical, physiological, and biological background of this valuable fluid. In addition, a detailed discussion of CSF collection and its preanalytical and methodological implications is provided. In addition, the increasing number of disease-specific markers in CSF will be discussed. Finally, CSF analyses are brought into context with clinical syndromes, demonstrating the diagnostic value of CSF in neurological clinical practice. Cerebrospinal Fluid in Clinical Neurology
helps understand preanalytical and analytical issues of CSF diagnostics and will be a valuable reference for the interpretation of CSF results during the clinical work-up of neurological patients.Table of Contents
1. Introduction.- 2. History of CSF.- 3. Anatomy of CSF-related spaces.- 4. Physiology of CSF.- 4.1. CSF production.- 4.2. CSR resorption.- 4.3. Biological function of CSF.- 5. CSF collection.- 5.1. Techniques.- 5.2. Counter-indications and complications.- 5.3. Preanalytical aspects.- 6. Methods.- 6.1. Cell counts and cell staining.- 6.2. Glucose and Lactate.- 6.3. Proteins.- 6.4. Albumin.- 6.5. Immunoglobulins.- 6.6. Detection of infectious agents.- 6.7. Immunoflurescence.- 6.8. Others (biomarkers).- 7. CSF in clinical syndromes.- 7.1. Inflammatory disease of the CNS.- 7.1.1. Acute (bacterial, viral meningitis).- 7.1.2. Chronic (MS).- 7.2. Inflammatory diseases of the PNS.- 7.2.1. Acute (GBS, Neuroborreliosis).- 7.2.2 Chronic (CIDP).- 7.3. Neoplastic and paraneoplastic neurological disorders.- 7.4. Dementias and degenerative disorders.- 7.5. Cerebral bleedings.- 7.6. CSF rhinorrhoea and otorrhoea. 8. Guidelines.