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- Offers clear insight into the pathogenesis of primary Raynaud’s and various secondary forms of Raynaud’s
- Expands on the clinical and laboratory assessment of patient presenting with Raynaud’s
- Provides comprehensive guidance into treatment of mild and complicated cases of Raynaud’s
This book comprehensively reviews the understanding of a disorder that continues to challenge primary care clinicians and specialists. Raynaud’s phenomenon is an inappropriate and exaggerated response of the digital and cutaneous circulation to cold environmental temperatures. It is common, often causing significant morbidity and it is a major challenge for physicians at every level and specialty. A comprehensive review of Raynaud’s is now timely because of the incredible progress in understanding the molecular mechanisms of the normal regulation of cutaneous blood flow and how disease can disrupt the function of these specialized vessels. Likewise, the clinical implications of Raynaud’s phenomenon are better appreciated with studies defining its prevalence, the associated diseases, and new treatment approaches for patients suffering from it. The nomenclature used to classify cases has changed over the years and is important to understand these terms both for clinical care and research. This fully updated second edition comprehensively discusses various causes of Raynaud’s phenomenon including childhood Raynaud’s phenomenon, Raynaud’s phenomenon secondary to connective tissue disease, occupational causes, and a variety of other associated disorders. Careful consideration is given to the diagnosis of Raynaud’s phenomenon with state of the art discussion of nailfold capillary examination, non-invasive imaging, angiography, and appropriate serological testing. The concept that Raynaud’s phenomenon is associated with systemic disease or can be the manifestation of a systemic vasospastic disorder is also presented. In addition to reviewing both non-drug and drug therapy for patients with Raynaud’s phenomenon, this volume provides a practical approach in specific clinical situations by presenting problematic cases and the authors’ expert opinions on therapy. It also discusses mechanisms contributing to the vascular dysfunction of primary Raynaud’s phenomenon and the vascular disease of secondary Raynaud’s phenomenon. Engaging readers with case vignettes and a plethora of visual aids, Raynaud’s Phenomenon: From Pathogenesis to Management is a state-of-the-art, authoritative reference and invaluable contribution to the literature that will be of interest to adult and pediatric physicians, rheumatologists, and clinical and basic researchers. Table of Contents- Chapter 1 Historical perspective of Raynaud’s phenomenon
Andrea Fava and Francesco Boin - Chapter 2 Definition, Nomenclature, And Diagnostic Criteria
Serena Guiducci & Marco Matucci Cerinic - Chapter 3 Epidemiology of Raynaud’s Phenomenon
Adam Maundrell, Susanna M. Proudman - Chapter 4 Thermoregulation: The Normal Structure and Function of the Cutaneous Vascular System
Nicholas A. Flavahan - Chapter 5 Pathophysiological Regulation of the Cutaneous Vascular System in Raynaud’s Phenomenon
Nicholas A. Flavahan - Chapter 6 Primary Raynaud’s Phenomenon
Ariane L. Herrick - Chapter 7 Raynaud Phenomenon In The Pediatric Age
Francesco Zulian, Clare Pain - Chapter 8 Secondary Raynaud’s phenomenon
Voon H. Ong, Christopher P. Denton - Chapter 9 Traumatic Vasospastic Disease
Ami A. Shah - Chapter 10 Other Secondary Causes
Marina Anderson, Michael Hughes - Chapter 11 Raynaud’s Mimics
Zsuzsanna H. McMahan and Julie Paik - Chapter 12 Nailfold Capillaries
Maurizio Cutolo and Vanessa Smith - Chapter 13 Non-Invasive methods of assessing Raynaud’s phenomenon
Andrea Murray and John D. Pauling - Chapter 14 Angiography
Yannick Allanore, Jean-Luc Drappé, Thomas Reifsnyder - Chapter 15 Autoantibodies in Raynaud’s Phenomenon
Victoria Flower, John. D. Pauling, Neil McHugh - Chapter 16 Systemic Vasospasm
Laura K. Hummers - Chapter 17 Clinical Outcome Measures in Raynaud’s Phenomenon
Dinesh Khanna, Heather Gladue, James R. Seibold - Chapter 18 Design and reporting of randomised controlled trials for Raynaud’s phenomenon
Jack Wilkinson - Chapter 19 Non-drug Approaches to Treating Raynaud’s Phenomenon
Linda Kwakkenbos, Brett D. Thombs - Chapter 20 Drug Treatment of Raynaud’s Phenomenon
Janet E. Pope - Chapter 21 Management of digital ischemia
Antonia Valenzuela, Rasidat Adeduntan, Lorinda Chung - Chapter 22 Surgical Management
Lindsay Muir - Chapter 23 Practical Approaches to Treatment: Case Studies
Fredrick M. Wigley
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