- Presents fetal and neonatal brain diseases using a unified approach that stresses their mutual relationship
- Considers the role of all the neuroradiological techniques in evaluation of the developing brain
- Pays special attention to the role of advanced MR techniques in the clinical setting
- Matches clinical and neuroradiological aspects for the entire range of CNS pathology during fetal and neonatal life
During the past ten years, neuroradiological evaluation of the neonatal and the prenatal brain has advanced tremendously. However, even though they are intrinsically related, these two critical stages in brain development are usually studied and presented separately. In order to have a sound understanding of neonatal brain diseases, detailed knowledge of prenatal brain pathology is immensely helpful; conversely, knowledge of neonatal brain disease is a prerequisite for understanding many fetal brain lesions.
The novel aim of this book is to illustrate, using a unified approach, the normal appearances and diseases of the fetal and the neonatal central nervous system, with matching of clinical and neuroradiological aspects for the entire range of CNS pathology. All of the neuroradiological techniques are considered, but the principal focus is on both traditional and advanced magnetic resonance imaging techniques. The use of ultrasound during fetal life is described only in terms of its role as the gold standard, but its application during neonatal life is discussed in more detail. The roles of computed tomography and traditional angiography are also discussed and evaluated
Table of ContentsImaging Techniques in Fetuses and Neonates: Fetal MRI. Neonatal Ultrasound: brain and spine. CT in newborns. MR. Angiography.- Normal development: CNS maturation during fetal life: biology, biometrics and MR. Normal CNS in premature neonates. Normal CNS in term neonates.- Congenital malformations: Screening for syndromic patients. Holoprosencephalies, Septo-optic dysplasia , Hypotalamic and Pituitary malformations. Anomalies of the cerebral commissures. Malformation of cortical development. Malformation of brain stem and cerebellum. Anomalies of the face and skull. Congenital malformations of the ear. Congenital malformations of the eye. Congenital anomalies of the spine and cranio-vertebral junction. Congenital anomalies of cerebral vasculature.- The Phakomateoses in fetuses and neonates: Tuberous sclerosis. Sturge-Weger Disease. Other. - Ischemic and Haemorrhagic lesions: Focal and multifocal ischemic /haemorrhagic lesion: fetus and newborn. CNS injuries in multiple pregnancies. Peri-intraventricular haemorrhage of the premature. Leukoencephalopathy of the premature. Hypoxic-ischemic encephalopathy. Brain vascular injuries associates to non CNS diseases.- Metabolic and toxic diseases: Metabolic and toxic disease affecting fetal brain. Endogenous toxic and metabolic disease in newborn. Metabolic and toxic disease with neonatal onset. HIE mimickers.- CNS trauma: Fetal CNS trauma. CNS trauma and delivery. Accidental trauma in newborn. Non-accidental trauma in newborns. – Neoplasms: Fetal CNS neoplasms. Neonatal CNS neoplasms.- Infections and Inflammation: Fetal and congenital infections. Neonatal CNS acquired infection in premature and term newborns.
