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Neurodegenerative Diseases


GALIMBERTI / SCARPINI  

Neurodegenerative Diseases
Clinical Aspects, Molecular Genetics and Biomarkers

407 Seiten, 2. Auflage, 2018
23 Abbildungen

  • Includes four new chapters on recent developments
  • Translational (from bench to bedside) approach
  • Covers neurodegeneration in classically non-degenerative disorders
This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimerís disease, frontotemporal lobar degeneration, Lewy body dementia,Parkinsonís disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases.

Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of basic research into biomarkers for early diagnosis, particularly to identify peripheral biomarkers.

In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis.

Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.

Table of Contents
  • Genetics and Epigenetics in the Neurodegenerative Disorders of the Central Nervous System
    Chiara Fenoglio
  • Diagnosis of Alzheimerís Disease Typical and Atypical Forms
    Laura Ghezzi
  • Genetic Complexity of Early-Onset Alzheimerís Disease
    Mahdi Ghani, Christiane Reitz, Peter St George-Hyslop, Ekaterina Rogaeva
  • Genetic Risk Factors for Complex Forms of Alzheimerís Disease
    Cťline Bellenguez, Jean-Charles Lambert
  • Role of Cerebrovascular Disease in Cognition
    Ana Verdelho
  • Risk Factors and Prevention in Alzheimerís Disease and Dementia
    Giulia Grande, Davide L. Vetrano, Francesca Mangialasche
  • Diagnosis of Frontotemporal Dementia
    Giorgio Giulio Fumagalli
  • Autosomal Dominant Frontotemporal Lobar Degeneration: From Genotype to Phenotype
    Maria Serpente, Daniela Galimberti
  • Genetic Risk Factors for Sporadic Frontotemporal Dementia
    Raffaele Ferrari, Claudia Manzoni, Parastoo Momeni
  • Alzheimerís Disease and Frontotemporal Lobar Degeneration: Mouse Models
    Lars M. Ittner, Wei S. Lee, Kristie Stefanoska, Prita R. Asih, Yazi D. Ke
  • Fluid Biomarkers in Alzheimerís Disease and Frontotemporal Dementia
    Niklas Mattsson, Sotirios Grigoriou, Henrik Zetterberg
  • Biomarkers for Alzheimerís Disease and Frontotemporal Lobar Degeneration: Imaging
    Marco Bozzali, Laura Serra
  • Genotypic and Phenotypic Heterogeneity in Amyotrophic Lateral Sclerosis
    Nicola Ticozzi, Vincenzo Silani
  • Lewy Body Dementia
    L. Bonanni, R. Franciotti, S. Delli Pizzi, A. Thomas, M. Onofrj
  • Rare Dementias
    Camilla Ferrari, Benedetta Nacmias, Sandro Sorbi
  • Neurodevelopmental and Neurodegenerative Alterations in the Pathophysiology of Schizophrenia: Focus on Neuro-Immuno-Inflammation
    Bernardo DellíOsso, M. Carlotta Palazzo, A. Carlo Altamura
  • Parkinsonís Disease: Contemporary Concepts and Clinical Management
    Vanessa Carvalho, Carlota Vicente Cunha, Jo„o Massano
  • Neurodegeneration and Multiple Sclerosis
    Axel Petzold



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