- Presents a comprehensive overview of the biochemical composition, molecular organization, morphologic structure, physiology, and metabolism of the vitreous body of the eye
- Highlights both the advances in vitreo-retinal surgery of today with text and video of surgery, along with the non-surgical approaches of the future, namely pharmacologic vitreolysis
- Clinicians can use this text as a basic science reference manual and researchers will obtain a better understanding of the problems that confront clinicians, helping direct their research to the areas relevant to clinical problems that need development
Vitreous: In Health and Disease presents a comprehensive overview of the biochemical composition, molecular organization, morphologic structure, physiology, and metabolism of the vitreous body of the eye. The pathobiology of vitreous and vitreoretinal disorders is discussed within the context of derangements of normal biology and of a shared basic pathobiology. With emphasis on therapeutics, this book highlights not only the advances in vitreo-retinal surgery of today with text and video recordings of surgery, but also the non-surgical approaches of the future, namely pharmacologic vitreolysis.
Vitreous: In Health and Disease examines such developmental and inherited disorders as dominant exudative vitreoretinopathy and Wagner's disease, connective tissue disorders, including Marfan's syndrome and Stickler syndrome, cellular invasion through trauma, inflammation, and neoplasia, and the effects of surgical intervention through vitrectomy, photocoagulation, cryopexy, and intravitreal injections. Clinicians will be able to use this text as a basic science reference manual and researchers will obtain a better understanding of the problems that confront clinicians, which should help them direct their research to the areas relevant to clinical problems that need development.
Table of ContentsI. BIOCHEMISTRY.- A. Vitreous Proteins.- B. Vitreous Glycosaminoglycans.- C. Hereditary Vitreo-Retinopathies.- D. Proteomics of Fetal Hyaloid Vasculature Regression.- E. Diabetic Vitreopathy.- F. Vitreous Biochemistry & Artificial Vitreous.-
II. ANATOMY, DEVELEOPMENT & AGING.- A. Vitreous Embryology.- B. Myopic Vitreopathy.- C. Vitreous Aging & Posterior Vitreous Detachment.- D. Hyalocytes.- E. Vitreo-Retinal Interface & Inner Limiting Membrane.- F. Imaging Vitreous.-
III. PATHOLOGY/PATHOBIOLOGY.- A. Congenital Vascular Vitreo-Retinopathies.- B. Anomalous PVD & Vitreoschisis.- C. Pathology of Vitreo-Maculopathies.- D. Vitreo-Macular Traction & Holes (Pseudo, Lamellar & Full-Thickness Macular Holes).- E. Vitreo-Papillary Adhesion/Traction.- F. Vitreous in the Pathobiology of Macular Pucker.- G. Vitreous in AMD.- H. Peripheral Vitreo-Retinal Pathology.- I. Role of Vitreous in Retinal Detachment Pathogenesis.- J. Cell Proliferation at Vitreo-Retinal Interface in PVR & Related Disorders.- K. Vitreous in Retino-Vascular Diseases and Diabetic Macular Edema.- L. Proliferative Diabetic Vitreo-Retinopathy.-
IV. PHYSIOLOGY & PHARMACOTHERAPY.- A. Vitreous in Ocular Physiology.- B. Oxygen in Vitreo-Retinal Physiology and Pathology.- C. Vitreous and Iris Neovascularization.- D. Physiology of Accommodation & Role of Vitreous.- E. Principles and Practice of Intravitreal Application of Drugs.- F. Pharmacotherapy of PVR.- G. Physiology of Vitreous Substitutes (SiO, PFCs).-
V. VITREO-RETINAL SURGERY.- A. Posterior Vitreo-Retinal Surgery.- 1. Vitreo-Retinal Surgery in Age-Related Macular Degeneration.- 2. Vitreo-Maculopathy Surgery.- 3. Chromodissection in Vitreo-Retinal Surgery.- 4. Macular Hole & Macular Pucker Surgery with Special Emphasis on Re-Operations.- 5. Vitrectomy for Diabetic Vitreo-Retinopathy & Diabetic Macular Edema.- 6. Surgery of Arterial and Venous Retino-Vascular Diseases.- B. Peripheral Vitreo-Retinal Surgery.- 1. History of Vitrectomy Instrumentation.- 2. Modern Vitrectomy Cutters.- 3. Future Vitrectomy Technologies.- 4. Prophylaxis and Cure of Retinal Detachment.- 5. Surgical Management of Retinal Detachment with PVR.- 6. Retinectomy in Recalcitrant Retinal Detachments.- 7. Pneumatic Retinopexy.- 8. Floaters and Vision - Current Concepts and Management Paradigms.- 9. Rare Indications for Vitrectomy: Tumor Excision, Optic Nerve Pits, Malignant Glaucoma.-
VI. PHARMACOLOGIC VITREOLYSIS.- A. Pharmacologic Vitreolysis.- B. History of Pharmacologic Vitreolysis.- C. Pharmacologic Vitreolysis with Tissue Plasminogen Activator.- D. Pharmacologic Vitreolysis with Plasmin.- 1. Basic Science Experiments.- 2. Clinical Studies.- E. Pharmacologic Vitreolysis with Ocriplasmin.- 1. Basic Science of Ocriplasmin Pharmacologic Vitreolysis.- 2. Clinical Studies of Ocriplasmin Pharmacologic Vitreolysis.- F. Hyaluronidase as a Vitreous Liquefactant.- G. Pharmacologic Vitreolysis with Dispase (Vitreolysin™).- H. Chondroitinase as a Vitreous Interfactant.
