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- Assists in the often complex diagnosis of musculoskeletal tumors and tumor-like conditions
- Highlights clinical, radiological, and histological correlations
- Discusses the implications of recently identified biological and genetic features
- Based on the Rizzoli case archive of more than 40,000 lesions
This book, now in a second revised edition, casts light on the often complex diagnosis of musculoskeletal tumors and tumor-like conditions by drawing on the experience of the Rizzoli Orthopedic Institute during more than 100 years of treatment and research in the field. The different entities are described from a multidisciplinary perspective, highlighting clinical, radiological, and histological correlations. Particular emphasis is placed on differential diagnosis, which often needs to take into account nontumoral conditions. The recent identification of further significant biological and genetic features, and the impact of these discoveries on the classification of round cell tumors, vascular lesions, and spindle/pleomorphic entities in bone, is also extensively discussed. The Rizzoli case archive dates back to September 1900 and contains the original material relating to more than 29,000 bone lesions and 11,000 soft tissue lesions. It is a fabulously rich resource, and this book will be invaluable for pathologists, radiologists, and clinicians at all levels of experience Table of ContentsINTRODUCTION- 1 Epidemiology of Bone Lesions.-
- 2 Classification of Primary Bone Lesions.-
- 3 General Principles of Bone Pathology.-
- 4 Epidemiology of Soft Tissue Lesions.-
- 5 Classification of Soft Tissue Lesions.-
- 6 General Principle of Soft Tissue Pathology and Molecular Alterations in Musculoskeletal Lesions.-
- 7 General Principles of Imaging.-
- 8 Staging.-
PSEUDOTUMORAL AND BENIGN LESIONS OF BONE - 9 Simple Bone Cyst (Unicameral Bone Cyst).-
- 10 Langerhans Cell Histiocytosis.-
- 11 Histiocytic Fibroma.-
- 12 Fibrous Dysplasia.-
- 13 Osteofibrous Dysplasia of Long Bones.-
- 14 Desmoid Fibroma (Desmoplastic Fibroma of Bone).-
- 15 Chondromas.-
- 16 Osteochondromas.-
- 17 Chondroblastoma.-
- 18 Chondromyxoid Fibroma.-
- 19 Osteoid Osteoma.-
- 20 Osteoblastoma.-
- 21 Aneurysmal Bone Cyst (ABC).-
- 22 Giant Cell Tumor.-
- 23 Biology of Giant Cell Tumor.-
- 24 Other Rare Pseudotumoral Lesions.-
- 25 Other Rare Benign Lesions.-
III BENIGN LESIONS OF SOFT TISSUES- 26 Myositis Ossificans.-
- 27 Pigmented Villonodular Synovitis and Giant Cell Tumor of the Tendon Sheaths (Tenosynovial Giant Cell Tumor).-
- 28 Synovial Chondromatosis.-
- 29 Fibromatosis (All Types).-
- 30 Lipomas.-
- 31 Neurofibroma.-
- 32 Schwannoma.-
- 33 Other Rare Conditions of Pseudotumoral and Benign Lesions of Soft Tissues.-
IV PRIMARY MALIGNANT TUMORS- 34 Chondrosarcomas (CHS).-
- 35 Biology of Conventional Chondrosarcoma.-
- 36 Osteosarcomas (OS).-
- 37 Biology of Osteosarcomas.-
- 38 Chemotherapy of Osteosarcoma.-
- 39 Small Blue Round Cell Tumors.-
- 40 Biology of Ewing Sarcoma.-
- 41 Chemotherapy of Ewing Sarcoma.-
- 42 Fibroblastic/Myofibroblastic Tumors.-
- 43 Nerve Sheath Tumor.-
- 44 Smooth and Striated Muscle.-
- 45 Sarcomas with Uncertain Differentiation.-
- 46 Vascular Tumors.-
- 47 Liposarcomas.-
- 48 Chemotherapy of Soft Tissue Sarcomas.-
- 49 Adamantinoma.-
- 50 Notochordol Differentiation.-
- 51 Other Rare Malignant Lesions.-
SYSTEMIC LESIONS - 52 Primary Lymphoma of Bone.-
- 53 Multiple Myeloma.-
- 54 Hodgkin's Disease in Bone.-
- 55 Metastatic Lesions.
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