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Myelin Repair and Neuroprotection in Multiple Sclerosis


Myelin Repair and Neuroprotection in Multiple Sclerosis

287 Seiten, 1. Auflage, 2013
43 Abbildungen

  • First book on this topic
  • Authorship from many of the major players in the field of MS and myelin repair
  • Of equal interest to academic clinical neurologists and neuroscientists
Myelin Repair and Neuroprotection in Multiple Sclerosis presents an up-date on the translational potential of promoting remyelination in multiple sclerosis (MS). A number of research frontiers still exist in this challenging disease. The cause remains elusive, preventing breakthroughs in its prevention. The move towards oral immunomodulatory therapies has been a major advance, as has the finding of new genes linked to susceptibility that may open the door to new therapeutic approaches.

However, a frontier that has been making significant strides in recent years has been that surrounding the neurobiology of myelin regeneration and axon protection: such have been the advances that clinical translation is on the cusp of being achieved. Two broad approaches to therapeutic enhancement of remyelination are envisaged: promoting endogenous remyelination by targeting cells present in the CNS, or, replacing lost myelinating cells from exogenous sources. Current research on oligodendrocyte biology, the pathology of MS, imaging of lesions and the biology of remyelination are paving the way toward opening this new translational frontier.

  • 1. Development of Oligodendrocytes in the Vertebrate CNS 1
    Robert H. Miller
  • 2. Demyelination and Remyelination in Multiple Sclerosis
    Lars Bø, Margaret Esiri, Nikos Evangelou, and Tanja Kuhlmann
  • 3. Microglial Function in MS Pathology
    Trevor J. Kilpatrick and Vilija G. Jokubaiti
  • 4. Endogenous Remyelination in the CNS
    Robin J.M. Franklin, Chao Zhao, Catherine Lubetzki, and Charles ffrench-Constant
  • 5 Exogenous Cell Myelin Repair and Neuroprotection in Multiple Sclerosis
    Ian D. Duncan and Yoichi Kondo
  • 6. A Peripheral Alternative to Central Nervous System Myelin Repair
    V. Zujovic and A. Baron Van Evercooren
  • 7. Immune Modulation and Repair Following Neural Stem Cell Transplantation
    Tamir Ben-Hur, Stefano Pluchino, and Gianvito Martino
  • 8. Axonal Protection with Sodium Channel Blocking Agents in Models of Multiple Sclerosis
    Joel A. Black, Kenneth J. Smith, and Stephen G. Waxman
  • 9. Effects of Current Medical Therapies on Reparative and Neuroprotective Functions in Multiple Sclerosis
    Jack P. Antel and Veronique E. Miron
  • 10. Imaging of Demyelination and Remyelination in Multiple Sclerosis
    Douglas L. Arnold, Catherine M. Dalton, Klaus Schmierer, G. Bruce Pike, and David H. Miller
  • 11. Designing Clinical Trials to Test Neuroprotective Therapies in Multiple Sclerosis
    P. Connick, M. Kolappan, A. Compston, and S. Chandran
  • Index


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