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Mechanisms and Emerging Therapies in Tremor Disorders


Mechanisms and Emerging Therapies in Tremor Disorders
Contemporary Clinical Neuroscience

492 Seiten, 1. Auflage, 2013
105 Abbildungen

  • Detailed description of the various forms of tremor encountered in humans
  • Covers recent advances in methodologies and techniques of assessment, and provides practical information for the daily management
  • Intended for a large audience of scientists, clinicians including neurologists and neurosurgeons, internists, fellows, trainees, biologists, biomedical and electrical engineers
Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex up to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness and damping are all factors influencing features of tremor.

This book discusses the pathophysiology of tremor including membrane mechanisms and rodent models, the advances in genetics and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment, and provides practical informations for the daily management. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced. Future challenges are also presented.

Table of Contents

Part I Fundamental Aspects
  • 1 Definition of Tremor - Giuliana Grimaldi and Mario Manto
    2 Membrane Mechanisms of Tremor
  • - Aasef G. Shaikh, Lance M. Optican, and David S. Zee
  • 3 Rodent Models of Tremor - Hideto Miwa
  • 4 Advances in the Genetics of Human Tremor - Fabio Coppedè
  • 5 Musculoskeletal Models of Tremor - Dingguo Zhang and Wei Tech Ang

Part II The Various Forms of Tremor in Clinical Practice: Presentation and Mechanisms
  • 6 Physiologic Tremor - Rodger J. Elble
  • 7 Rest Tremor - Giuliana Grimaldi and Mario Manto
  • 8 Postural Tremors
    - Jean-François Daneault, Benoit Carignan, Fariborz Rahimi, Abbas F. Sadikot, and Christian Duval
  • 9 Isometric Tremor - Dennis A. Nowak, Hans-Jürgen Gdynia, and Jan Raethjen
  • 10 Essential Tremor and Other Forms of Kinetic Tremor - Elan D. Louis
  • 11 Dystonic Tremor - Stefania Lalli and Alberto Albanese
  • 12 Orthostatic Tremor - Julián Benito-León, Andrés Labiano-Fontcuberta, and Elan D. Louis
  • 13 Vocal Tremor - Katherine A. Kendall
  • 14 Update in Familial Cortical Myoclonic Tremor
    with Epilepsy - Eloi Magnin, Pierre Labauge, Lucien Rumbach, and Marie Vidailhet
  • 15 Posttraumatic Tremor and Other Posttraumatic Movement Disorders
    Jose Fidel Baizabal-Carvallo and Joseph Jankovic
  • 16 Psychogenic Tremor - Luis Redondo-Vergé and Natividad Carrion-Mellado
  • 17 Tremor in Childhood - Padraic J. Grattan-Smith and Russell C. Dale
Part III Assessment of Tremor: Clinical, Neurophysiological and Neuroimaging Aspects
  • 18 Assessment of Tremor: Clinical and Functional Scales - Giuliana Grimaldi and Mario Manto
  • 19 Instrumentation: Classical and Emerging Techniques - Peter H. Kraus
  • 20 Signal Processing - James McNames
  • 21 Diffusion Imaging in Tremor - Johannes C. Klein
  • 22 Metabolic Networks in Parkinson’s Disease - Michael Pourfar, Martin Niethammer, and David Eidelberg
Part IV Therapies of Tremor
  • 23 Pharmacological Treatments of Tremor - Giuliana Grimaldi and Mario Manto
  • 24 Thalamotomy- Julie J. Berk and Olga S. Klepitskaya
  • 25 Deep Brain Stimulation - Ioannis U. Isaias and Jens Volkmann
  • 26 Dopaminergic Influences on Rest and Action Parkinsonian Tremors
    and Emerging Therapies for Tremor - Quincy J. Almeida, Fariborz Rahimi, David Wang, and Farrokh Janabi-Sharifi
  • Index


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