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- Includes new chapters on non-Caucasian stroke, advanced imaging and cerebral venous thrombosis
- Covers important & novel results from large datasets, as genetics continues to advance at an unprecedented rate
- Free for readers: Additional questions about the book content in the Springer Nature Flashcards app
This revised, expanded third edition updates the reader on this fast moving field as well providing an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genome-wide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed. Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics. Each chapter now contains teaching/training MCQs to help with retention of information learnt from each chapter and this will be of considerable use to those training or about to the examined in the field of inherited stroke. Additional questions via app: Download the Springer Nature Flashcards app for free and use exclusive additional material to test your knowledge. Table of Contents- Introduction
- Familial Occurrence and Heritability of Stroke
- Genetic Association Studies and Next Generation Sequencing in Stroke: Methods
- Sickle Cell Disease
- Fabry Disease
- Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL)
- Stroke-Like Episodes in Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes (MELAS)
- Other Monogenetic Stroke Disorders
- The Genetics of Cerebral Microbleeds
- The Genetics of Cerebral Aneurysms and Other Vascular Malformations
- Intracerebral Hemorrhage and Cerebral Amyloid Angiopathy
- White Matter Disease
- Genetics of Small Vessel Disease
- Genetics of Carotid Atherosclerosis
- Genetics of Cervical Artery Dissection
- Stroke Genetics in China
- Stroke Pharmacogenetics
- Cerebral Venous Thrombosis: Genetic Aspects
- Multi-Omics Approaches to Discovering Acute Stroke Injury and Recovery Mechanisms
- Genetic Research and the Law
- Diagnosis, Investigation, Treatment and Management of Young Stroke in Clinic
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