- Illustrated with detailed line-art and photographs
- Covers patient selection, treatment strategy, outcomes, and safety concerns
- Provides insight into the latest clinical applications of image-guided diagnosis and treatment
This book encompasses an up-to-date, comprehensive review of the state-of-the-art for prostate gland preserving therapies.
It provides insight into the latest research and clinical applications of image-guided diagnosis and minimally invasive focal, gland-preserving treatment for prostate cancer. Fully updated and revised, this text evaluates the scientific evidence for the evolving trend to treat intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, image-targeted therapy methods.
Imaging and Focal Therapy of Early Prostate Cancer, Third Edition opens with a discussion of why patients and clinicians should consider focal therapy, then moves on to consider the question of active surveillance versus focal therapy from a global perspective, with chapters on North American, European, Southeast Asian, and South American perspectives. From there, chapters cover the scientific foundation of focal therapy, current and new approaches to image cancer foci within the prostate (multiparametric ultrasonography, multiparametric magnetic resonance imaging, etc.) and various biopsy techniques.
Following this is detailed coverage of patient selection, treatment strategy, adjuvants to enhance therapy, outcomes, and patient centered interests, followed by a discussion of the strengths and limitations of various therapeutic modalities, such as cryotherapy, high intensity focused ultrasound, and photodynamic therapy, follows. The final sections of the book cover the assessment of focal therapy outcomes and look forward to the future of focal therapy for prostate cancer.
Written by experts in the field and lavishly illustrated with detailed line-art and photographs, this text is designed as a comprehensive resource for urologists, radiation oncologists, medical oncologists, radiologists, uropathologists, molecular biologists, biomedical engineers, residents, fellows, nurses and allied professionals, and researchers with an interest in the diagnosis and novel targeted treatment of prostate cancer.
Table of ContentsSection 1: Why Focal Therapy?
- Chapter 1. Evolution in the Concept of Focal Therapy: the Story of Breast Cancer and Prostate Cancer
- Chapter 2. Targeted Therapy for Localized Kidney Cancer
- Chapter 3. Focal Therapy for Prostate Cancer: A Guide for Patients
Section 2: Global Perspective of Active Surveillance and Focal Therapy
- Chapter 4.Low-Risk Prostate Cancer in North America: Rationale, Uptake, and Limitations of Active Surveillance and Opportunities for Focal Therapy
- Chapter 5. Focal Therapy and Active Surveillance in Europe
- Chapter 6. Focal Therapy and Active Surveillance of Prostate Cancer in East and Southeast Asia
Section 3: Scientific Foundation for the Focal Therapy Concept
- Chapter 7. Pathologic Rationale for Focal Therapy of Prostate Cancer: Elucidating Tumor Characteristics and Biology
- Chapter 8. Identifying and Characterizing the Index Lesion
- Chapter 9. Utilizing Biopsy-Based Genomic Assays to Risk-Stratify Patients
- Chapter 10. Patient Selection for Focal Therapy of Prostate Cancer
- Chapter 11. Prostate Focal Therapy: Definitions and Common Terminology
Section 4: Multiparametric MRI and ARFI Imaging of the Prostate
- Chapter 12. Reading and Reporting Standards: The Prostate Imaging Reporting And Data System – What Is It and What Can It Do?
- Chapter 13. Role of Magnetic Resonance Imaging in Prostate Cancer Assessment
- Chapter 14.Optimizing Multiparametric Magnetic Resonance Imaging for a Focal Therapy Practice: Quality Improvement
- Chapter 15. Acoustic Radiation Force Impulse Imaging for Targeting: Correlation with Histology
Section 5: Prostate Biopsy Techniques
- Chapter 16. In-Bore Magnetic Resonance Imaging-Targeted Biopsy
- Chapter 17. Multiparametric MRI-TRUS Fusion Biopsy, Outcomes, and Commercial Systems
- Chapter 18. Detecting, Localizing, and Treating the Multiparametric Magnetic Resonance Imaging Invisible Lesion: Utilizing Three-Dimensional Transperineal Mapping
- Chapter 19. Multiparametric Transrectal Ultrasound Biopsy
- Chapter 20. Robotic Magnetic Resonance Imaging Targeting for Biopsy and Therapy
Section 6: Technologies for Focal Therapy: Transperineal Approach
- Chapter 21. In-Bore Transperineal Magnetic Resonance Imaging-Guided Laser Ablation
- Chapter 22. Focal Cryoablation
- Chapter 23. Photodynamic Therapy for Early Prostate Cancer
Section 7: Technologies for Focal Therapy: Transrectal Approach
- Chapter 24. High-Intensity Focused Ultrasound
- Chapter 25. Transrectal Laser Focal Therapy of Prostate Cancer
Section 8: New Approaches and Applications of Focal Therapy
- Chapter 26. Focal Therapy for Prostate Cancer: a Molecular Biology Approach with TRAIL
- Chapter 27. Focal Brachytherapy and Intensity Modulated Radiation Therapy
- Chapter 28. Focal Therapy for Anterior Cancers (Originated from Transition Zone)
Section 9: Manipulating the Microenvironment for Optimization
- Chapter 29. The Story of Adjuvants to Boost the Performance of Cryoablation
- Chapter 30. 5-Alpha-Reductase Inhibition as a Secondary Preventive Strategy
Section 10: Determining Outcomes of Focal Therapy
- Chapter 31. Measuring Patient-Based Outcomes: Setting Realistic Expectations When Balancing Functional Outcomes with Cancer Control
- Chapter 32. Pathologic Assessment and Implications Following Focal Therapy of Prostate Cancer
- Chapter 33. Post-Treatment Surveillance Using Multiparametric Magnetic Resonance Imaging
- Chapter 34. Determining Focal Therapy Failure and Salvage Options
- Chapter 35. Positioning Focal Therapy from Consensus to Guidelines
