- Comprehensive guide to current diagnostic modalities
- Evidence based therapeutic approach including evolving biologic drugs
- Written by experts in the field
This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins.
The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field.
Written by experts in their field,
Crohn’s Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn’s disease, ulcerative colitis, and related autoimmune disorders.
Table of ContentsPart 1 Epidemiology
Chapter 1 Environmental Factors in the Epidemiology of Inflammatory Bowel Disease
Morten H. Vatn
Part 2 Immunobiology
Chapter 2 The Intestinal Immune System in Health
Per Brandtzaeg
Chapter 3 Understanding the Epithelial Barrier in Inflammatory Bowel Disease
Matthew A. Odenwald, Jerrold R. Turner
Chapter 4 Intestinal Microbiology and Ecology in Crohn's Disease and Ulcerative Colitis
Dirk Haller, Ludovica F. Butto
Chapter 5 The Immune System in Inflammatory Bowel Disease: Antimicrobial Peptides
Charles L. Bevins
Chapter 6 Vascular Responses to Intestinal Inflammation
D. Neil Granger, Norman R. Harris
Chapter 7 Immunobiology of Human Dendritic Cells in Inflammatory Bowel Disease
Daniel C. Baumgart
Chapter 8 Immunobiology of T-Cells in Inflammatory Bowel Disease<
S. Snapper, D. Nguyen, A Biswas
Chapter 9 Immunobiology of B cells in Inflammatory Bowel Disease
Atsushi Mizoguchi, Atul K. Bhan
Chapter 10 Immune Cells: Monocytes and Macrophages
Gerhard Rogler
Chapter 11 Immune Functions of Epithelial Cells in Inflammatory Bowel Disease
Eric L. Campbell, Sean P. Colgan
Chapter 12 Autophagy and Endoplasmic Reticulum Stress
Arthur Kaser
Chapter 13 Matrix Metalloproteinases
Paolo Biancheri, Thomas T. MacDonald
Chapter 14 Paradigm of T-cell Differentiation in Inflammatory Bowel Disease
Takashi Nagaishi, Mamoru Watanabe
Chapter 15 Pharmacological Intervention Studies Using Mouse Models of Chronic Intestinal Inflammation
Cynthia Reinoso Webb, Matthew B. Grisham
Chapter 16 Stem Cells and Organoids to Study Epithelial Cell Biology in Inflammatory Bowel Disease
Jorge O. Múnera, James M. Wells
Part 3 Diagnostic Approach
Chapter 17 Enhanced Endoscopy
Ralf Kiesslich
Chapter 18 Magnetic Resonance Enterography
Patrik Rogalla, Luis Guimaraes
Chapter 19 Computed Tomography Enterography and Inflammatory Bowel Disease
J. G. Fletcher
Chapter 20 Ultrasound in Inflammatory Bowel Disease
A. Potthoff, C. Agné, M. Gebel
Chapter 21 Laboratory Evaluation, Including Novel Diagnostic Markers
M. Flamant, X. Roblin
Chapter 22 Pathology of Inflammatory Bowel Disease
Nora E. Joseph, Christopher R. Weber
Chapter 23 Objective Assessment of Clinical Disease Activity
Edouard Louis, Catherine Van Kemseke, Catherine Reenaers
Chapter 24 Objective Assessment of Endoscopic Disease Activity and Mucosal Healing
Britt Christensen, David T. Rubin
Chapter 25 Evaluation of Quality of Life in Crohn's disease and Ulcerative Colitis: What Is Health-Related Quality of Life?
Katrine Carlsen, Pia Munkholm, Johan Burisch
Chapter 26 Evaluation of Health Economics in Inflammatory Bowel Disease
Reena Khanna, Brian G. Feagan
Part 4 Therapy Crohn’s Disease
Chapter 27 The Natural History of Inflammatory Bowel Disease
Charles N. Bernstein
Chapter 28 Conventional Medica Management of Crohn's Disease: Sulfasalazine
Miquel A. Gassull, Eduard Cabré
Chapter 29 Steroid Therapy for Crohn's Disease
A. Hillary Steinhart
Chapter 30 Thiopurines in Crohns' disease
Adi Lahat, Rami Eliakim
Chapter 31 Conventional Medical Management of Crohn's Disease: Methotrexate
Grace Harkin, Laurence Egan
Chapter 32 Adalimumab for the Treatment of Crohn’s Disease
Remo Panaccione
Chapter 33 Biologic Therapy of Crohn's Disease: Certolizumab
Alessandro Armuzzi, Daniela Pugliese
Chapter 34 Biologic Therapy of Crohn's Disease: Infliximab
Jan-Michael A. Klapproth, Gary R. Lichtenstein
Chapter 35 Briakinumab and Ustekinumab: Anti-p40 Antibodies for Inflammatory Bowel Disease Treatment
Peter J. Mannon
Chapter 36 Biologic Therapy of Crohn's Disease: Natalizumab, Vedolizumab and anti-MadCAM
Pieter Hindryckx, Geert D’Haens
Chapter 37 Optimal Management of Fistulizing Crohn's Disease
Bruce Sands, Farhad Peerani
Part 5 Therapy Ulcerative Colitis
Chapter 38 Sulfasalazine and 5-Aminosalicylates for Ulcerative Colitis
Reena Khanna, John K. Marshall
Chapter 39 Conventional Therapy of Ulcerative Colitis: Corticosteroids
Kirstin Taylor, Peter R. Gibson
Chapter 40 Medical Management of Ulcerative Colitis: Conventional Therapy--Azathioprine
Barrett G. Levesque, Edward V. Loftus
Chapter 41 Calcineurin Inhibitors in Ulcerative Colitis
Andreas Fischer, Daniel C. Baumgart
Chapter 42 Biologic Therapy in Moderate-to-Severe Ulcerative Colitis: Infliximab
Mindy Lam, Brian Bressler
Chapter 43 Biologic Therapy of Ulcerative Colitis: Adalimumab
Walter Reinisch
Chapter 44 Biologic Therapy of Ulcerative Colitis: Golimumab
Mark A. Samaan, Peter M. Irving
Chapter 45 Biologic Therapy of Ulcerative Colitis: Natalizumab, Vedolizumab, Etrolizumab (rHUMab beta 7), antiMadCAM
Severine Vermeire
Chapter 46 Probiotics, Prebiotics, and Antibiotics in Inflammatory Bowel Disease
Paolo Gionchetti, Carlo Calabrese, Andrea Calafiore, Fernando Rizzello
Chapter 47 Biosimiliars in the Treatment of Inflammatory Bowel Disease
Vivian W. Huang, Richard N. Fedorak
Chapter 48 Step-up vs. Top-down Approach in Crohn’s Disease
Christine Y. Yu, Daniel W. Hommes
Chapter 49 Leucocytapheresis Therapy of Inflammatory Bowel Disease
Takanori Kanai
Chapter 50 Surgical Management of Crohn's Disease and Ulcerative Colitis
Robert R. Cima, John H. Pemberton
Part 6 Extraintestinal Manifestations
Chapter 51 Extraintestinal Manifestations: Autoimmune Hepatitis
Michael Manns, Nora Schweitzer
Chapter 52 Primary Sclerosing Cholangitis
Roger W. Chapman, Kate D. Williamson
Chapter 53 Autoimmune Pancreatitis and Other Organ Involvement
Go Kuwata, Terumi Kamisawa
Chapter 54 Cutaneous and Oral Manifestations of Inflammatory Bowel Disease
Caroline P. Allen, Susan M. Burge
Chapter 55 Arthritis, Arthropathy and Osteoporosis in Inflammatory Bowel Disease
Alistair Tindell, Hanna Johnsson, Iain B. McInnes
Part 7 Nutrition
Chapter 56 Nutrition in Inflammatory Bowel Disease
Alan L. Buchman
Part 8 Pregnancy, Family Planning and Pediatric Aspects
Chapter 57 Pregnancy and Fertility in Inflammatory Bowel Disease
Rebecca Matro, Uma Mahadevan
Chapter 58 Pediatric Aspects of Inflammatory Bowel Disease
Brendan Boyle, Jeffrey S. Hyams
Part 9 Surveillance and Prevention
Chapter 59 Management and Prevention of Infectious Diseases in Irritable Bowel Disease Patients
Kristine Macartney, Nigel Crawford
Chapter 60 Incidence of Cancer and Screening in Inflammatory Bowel Disease
Jimmy K. Limdi, Francis A. Farraye
Chapter 61 Inflammatory Bowel Diseases: How to Identify High Risk Patients
Jacques Cosnes, Harry Sokol
Part 10 Patient Perspective and Resources
Chapter 62 Patient Perspective on Inflammatory Bowel Disease
Ayesha Williams, Marjorie Merrick
Chapter 63 Patient Resources in Inflammatory Bowel Disease
Sanna Lönnfors, Marco Greco
